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FLASH GENE
Symbol CRLS1 contributors: mct - updated : 05-07-2007
HGNC name cardiolipin synthase 1
HGNC id 16148
Location 20p13-p12.3      Physical location : 5.986.738 - 6.020.694
Synonym name
  • chromosome 20 open reading frame 155
  • GCD10 homolog (S. cerevisiae)
  • Synonym symbol(s) CLS1, GCD10, dJ967N21.6, C20orf155
    EC.number 2.7.8.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text in a head-to-head orientation with the MCM8 gene
    STRUCTURE 31.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     salivary gland   highly
     stomach   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Crls1 (86.67 pc)
    homolog to chimpanzee CRLS1 (100.00 pc)
    Homologene
    FAMILY CDP-alcohol phosphatidyl transferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • intergrated to mitochondrial menbrane
  • basic FUNCTION
  • having a transferase activity
  • catalysing the synthesis of the mitochondrial phospholipid cardiolipin from cytidine diphosphate-diacylglycerol and phosphatidylglycerol
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS