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FLASH GENE
Symbol CRLF2 contributors: mct - updated : 22-04-2010
HGNC name cytokine receptor-like factor 2
HGNC id 14281
Location Xp22.33 or Yp11.2      Physical location : 1.264.886 - 1.331.530
Synonym name
  • cytokine receptor-like factor 2X
  • thymic stromal-derived lymphopoietin receptor
  • TSLP receptor
  • P2RY8/CRLF2 fusion
  • cytokine receptor CRL2 precusor
  • Synonym symbol(s) CRLF2X, CRL2, TSLPR, IL-XR, CRLF2Y
    DNA
    TYPE functioning gene
    STRUCTURE 16.66 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located in the same region than IL3AX and CSF2RAX
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1013 - 259 - 2002 11891057
    6 - 1579 42 371 - 2002 11891057
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticbasophil Homo sapiens
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative signal peptide
  • two N terminal fBN-III-like domains
  • four conserved cysteine residues
  • a WSXWS box-like motif
  • four potential N glycosylation sites
  • a unique transmembrane segment (TM1)
  • a cytoplasmic tail with box1
  • box 2-like motifs conserved in cytokine receptors
  • a cytoplasmic domain that can support proliferation of growth factor-dependent cells after homodimerization
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine delta1/TsIpr
    intraspecies homolog to IL3RAX
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 5 subfamily
  • CATEGORY protooncogene , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • mediating cellular signaling in response to TSLP
  • causal role of CRLF2 overexpression in lymphoid transformation
  • implicated as an important factor in B-ALL with diagnostic, prognostic, and therapeutic implications
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    type I cytokine receptor
    a component
  • common subunit to IL7RA
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds its ligand, thymic stromal lymphopoietin (TSLP), as part of a heterodimeric complex with the IL7 receptor subunit (IL7R)
  • TSLP/CRLF2 plays a significant role in the amplification of polarization and chemokine production, thereby contributing to allergic inflammation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    P2RY8-CRLF2 fusion in 7p100 of individuals with B-progenitor ALL (acute lymphoblastic leukemia) and 53p100 of individuals with ALL associated with Down syndrome
    tumoral     --over  
    in approximately 15p100 of adult and high-risk pediatric B-ALL that lack MLL, TCF3, TEL, and BCR/ABL rearrangements
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may provide a new prognostic marker for high-risk B-ALL
    Therapy target inhibition of CRLF2/JAK2 signaling may represent a therapeutic approach for high-risk B-ALL patients
    ANIMAL & CELL MODELS