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FLASH GENE
Symbol CRLF1 contributors: mct - updated : 08-07-2010
HGNC name cytokine receptor-like factor 1
HGNC id 2364
Corresponding disease
CISS1 cold-induced sweating syndrome 1
MCTHS muscular contraction, trismus, hyperthermia syndrome
Location 19p13.11      Physical location : 18.704.036 - 18.717.660
Synonym name
  • cold-induced sweating syndrome
  • class I cytokine receptor
  • cytokine type 1 receptor CRLP-1
    • Synonym symbol(s) NR6, CLF-1, CLF, ZCYTOR5
    DNA
    TYPE functioning gene
    STRUCTURE 13.61 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0561 PIK3R2 19q13.2-q13.4 phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta) IFI30 19p13.1 interferon, gamma-inducible protein 30 MGC12972 19p13.11 hypothetical protein MGC12972 RAB3A 19p13.1 RAB3A, member RAS oncogene family PDE4C 19P13.1 phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) LOC388516 19 LOC388516 KIAA1683 19p13.1 KIAA1683 JUND 19p13.1 jun D proto-oncogene LSM4 19p13.1 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) PGPEP1 19p13.11 pyroglutamyl-peptidase I PLAB MGC10812 19p13.11 hypothetical protein MGC10812 LOC388517 19 similar to MOST-1 protein MAPA 19p13.11 monocyte and plasmacytoid activated molecule SSBP4 19p13.1 single stranded DNA binding protein 4 ISYNA1 19p13.11 myo-inositol 1-phosphate synthase A1 DKFZp434I1916 ELL 19p13.1 elongation factor RNA polymerase II FKBP8 19p12 FK506 binding protein 8, 38kDa MGC2749 19p13.11 hypothetical protein MGC2749 UBA52 19p13.1-p12 ubiquitin A-52 residue ribosomal protein fusion product 1 FLJ20850 19p13.11 hypothetical protein FLJ20850 CRLF1 19p12 cytokine receptor-like factor 1 C19orf4 19p12 chromosome 19 open reading frame 4 FLJ11078 19p13.11 hypothetical protein FLJ11078 MECT1 19p13 mucoepidermoid carcinoma translocated 1 COMP 19p13.1 cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) RENT1 19p13.2-p13.11 regulator of nonsense transcripts 1 GDF1 19p13.1-p12 growth differentiation factor 1 LASS1-GDF1 19p12 LAG1 longevity assurance homolog 1 (S. cerevisiae), growth differentiation factor 1 transcription unit LASS1 19p13.1-p12 LAG1 longevity assurance homolog 1 (S. cerevisiae) LOC388518 19 LOC388518 COPE 19p13.1 coatomer protein complex, subunit epsilon DDX49 19p12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 HOMER3 19p13.11 homer homolog 3 (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1824 - 422 - 1998 9686600
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach     Homo sapiens
    Lymphoid/Immunelymph node     Homo sapiens
     spleen   highly Homo sapiens
     thymus   highly Homo sapiens
    Reproductivefemale systemplacenta  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text uterus, fetal heart
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • two fibronectin type-III domains
  • one Ig-like c2-type (immunoglobulin-like) domain
    • HOMOLOGY
    interspecies ortholog to murine Crlf1 (96 p100)
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 3 subfamily
    • CATEGORY immunity/defense , signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a regulatory role in the immune system and during fetal development
  • involved in the ciliary neurotrophic factor (CNTF)-receptor pathway, which is important for both development and maintenance of the nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ciliary neurotrophic factor (CNTF)-receptor pathway
    a component
  • CRLF1/CLC complex disrupts cartilage homeostasis and promotes the progress of osteoarthritis by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CISS1 , MCTHS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS