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FLASH GENE

Symbol

CRLF1

contributors: mct - updated : 08-07-2010

HGNC name	cytokine receptor-like factor 1
HGNC id	2364

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CISS1 cold-induced sweating syndrome 1 MCTHS muscular contraction, trismus, hyperthermia syndrome
Location	19p13.11      Physical location : 18.704.036 - 18.717.660
Synonym name	cold-induced sweating syndrome
	class I cytokine receptor
	cytokine type 1 receptor CRLP-1
Synonym symbol(s)	NR6, CLF-1, CLF, ZCYTOR5

DNA

TYPE	functioning gene
STRUCTURE	13.61 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004750 9 - 1824 NP_004741 - 422 - 1998 9686600

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach         Homo sapiens Lymphoid/Immune lymph node         Homo sapiens   spleen       highly Homo sapiens   thymus       highly Homo sapiens Reproductive female system placenta     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	uterus, fetal heart

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	two fibronectin type-III domains
	one Ig-like c2-type (immunoglobulin-like) domain

HOMOLOGY

interspecies

ortholog to murine Crlf1 (96 p100)

Homologene

FAMILY	type I cytokine receptor family
	type 3 subfamily

CATEGORY

immunity/defense , signaling cytokine , receptor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	playing a regulatory role in the immune system and during fetal development
	involved in the ciliary neurotrophic factor (CNTF)-receptor pathway, which is important for both development and maintenance of the nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

ciliary neurotrophic factor (CNTF)-receptor pathway

a component

CRLF1/CLC complex disrupts cartilage homeostasis and promotes the progress of osteoarthritis by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CISS1 , MCTHS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS