Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CRISP3 contributors: mct - updated : 16-02-2018
HGNC name cysteine-rich secretory protein 3
HGNC id 16904
Location 6p12.3      Physical location : 49.695.091 - 49.712.168
Synonym name specific granule protein (28 kDa)
Synonym symbol(s) CRS3, CRISP-3, SGP28, Aeg2, MGC126588
DNA
TYPE functioning gene
STRUCTURE 17.08 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2219 26 258 - 1996 8665901
8 - 2231 28 268 - 1996 8665901
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestiveintestinelarge intestinecolon  
 mouth    
 salivary gland    
Reproductivefemale systemovary    Homo sapiens
 female systemuterus    Homo sapiens
 male systemprostate    Homo sapiens
 male systemseminal vesicles    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningendometrium   Homo sapiens
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
Reproductiveepithelial cell Homo sapiens
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Crisp1
homolog to rattus Crisp-1
Homologene
FAMILY cysteine-rich secretory protein family
CATEGORY secretory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,granule
text
  • secreted and localized in specific granules in neutrophils
  • localizes to the luminal and glandular epithelium of the endometrium with increased immunoreactivity during the proliferative phase of the human cycle
  • basic FUNCTION
  • early response gene may be participating in the pathophysiology of the autoimmune lesions of Sjogren syndrome
  • potentially A1BG-CRISP3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP3
  • may participate in MSMB-independent activities during prostate tumourigenesis
  • inhibits hepatitis C virus at the initial phase of infection
  • roles for epithelial and neutrophil-derived CRISP3 in postmenstrual endometrial repair and regeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to alpha(1)B-glycoprotein (A1BG) in human serum/plasma
  • MSMB interact with cysteine-rich secretory protein 3 (CRISP3) in seminal plasma
  • CRISP3 is a direct target of ERG that is strongly overexpressed in Prostate carcinoma with the TMPRSS2-ERG fusion gene (
  • MSMB bind human CRISP3 (cysteine-rich secretory protein 3) with very high affinity
  • overexpression of CRISP3 in prostate tumor may maintain higher KLK3 expression and lower ANXA1 expression
  • CRISP3 binds specifically and with high affinity to MSMB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Sjogren syndrome
    tumoral     --over  
    in prostate cancer compared with normal prostate tissue
    tumoral     --over  
    strongly overexpressed in Prostate cancer with the TMPRSS2-ERG fusion gene (
    tumoral     --over  
    inprostate cancer with poor prognosis that could be due to its role in cell invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS