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FLASH GENE
Symbol CRISP3 contributors: mct - updated : 16-02-2018
HGNC name cysteine-rich secretory protein 3
HGNC id 16904
Location 6p12.3      Physical location : 49.695.091 - 49.712.168
Synonym name specific granule protein (28 kDa)
Synonym symbol(s) CRS3, CRISP-3, SGP28, Aeg2, MGC126588
DNA
TYPE functioning gene
STRUCTURE 17.08 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389394 6 similar to hypothetical protein DKFZp434D2328 MEP1A 6p21.2-p21.1 meprin A, alpha (PABA peptide hydrolase) GPR116 6p12.3 G protein-coupled receptor 116 GPR110 6p21.1 G protein-coupled receptor 110 FLJ22684 6p21.1 hypothetical protein FLJ22684 TNFRSF21 6p21.1-12.2 tumor necrosis factor receptor superfamily, member 21 CD2AP 6p12 CD2-associated protein GPR111 6p12.3 G protein-coupled receptor 111 GPR115 6p12.3 G protein-coupled receptor 115 C6orf138 6p12.3 chromosome 6 open reading frame 138 LOC389395 6 similar to heterogeneous nuclear ribonucleoprotein A3 RBMXP1 6p12.3 RNA binding motif protein, X chromosome pseudogene 1 LOC391925 6 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) MUT 6p21.2-p21.1 methylmalonyl Coenzyme A mutase C6orf139 6p12.3 chromosome 6 open reading frame 139 LOC389396 6 similar to BXMAS2-10 protein C6orf141 6p12.3 chromosome 6 open reading frame 141 RHAG 6p21.1-p11 Rhesus blood group-associated glycoprotein CRISP2 6p14-q21 cysteine-rich secretory protein 2 CRISP3 6p12.3 cysteine-rich secretory protein 3 PGK2 19p13.3 phosphoglycerate kinase 2 CRISP1 6p21.2-p21.1 cysteine-rich secretory protein 1 TFAP2BL1 6p12.3 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)-like 1 TFAP2B 6p12 transcription factor AP-2 beta (activating enhancer binding protein 2 beta) RPS17L4 6p12.3 ribosomal protein S17-like 4 FTHP1 6p21.1-p12 ferritin, heavy polypeptide pseudogene 1 LOC389397 6 hypothetical gene supported by BC000383; BC004432; NM_152857 LOC391926 6 similar to 40S ribosomal protein S15a PKHD1 6p12.2 polycystic kidney and hepatic disease 1 (autosomal recessive) IL17 2q31 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) IL17F 6p12 interleukin 17F SLC25A20P 6p12 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene MCM3 6p12 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) C6orf33 6p12.1 chromosome 6 open reading frame 33 EFHC1 6p12.1 EF-hand domain (C-terminal) containing 1 TRAM2 6p21.3 translocation associated membrane protein 2 TMEM14A 6p12.3 transmembrane protein 14A LOC391927 6 similar to class-alpha glutathione S-transferase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2219 26 258 - 1996 8665901
8 - 2231 28 268 - 1996 8665901
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestiveintestinelarge intestinecolon  
 mouth    
 salivary gland    
Reproductivefemale systemovary    Homo sapiens
 female systemuterus    Homo sapiens
 male systemprostate    Homo sapiens
 male systemseminal vesicles    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningendometrium   Homo sapiens
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
Reproductiveepithelial cell Homo sapiens
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Crisp1
homolog to rattus Crisp-1
Homologene
FAMILY cysteine-rich secretory protein family
CATEGORY secretory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,granule
text
  • secreted and localized in specific granules in neutrophils
  • localizes to the luminal and glandular epithelium of the endometrium with increased immunoreactivity during the proliferative phase of the human cycle
  • basic FUNCTION
  • early response gene may be participating in the pathophysiology of the autoimmune lesions of Sjogren syndrome
  • potentially A1BG-CRISP3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP3
  • may participate in MSMB-independent activities during prostate tumourigenesis
  • inhibits hepatitis C virus at the initial phase of infection
  • roles for epithelial and neutrophil-derived CRISP3 in postmenstrual endometrial repair and regeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to alpha(1)B-glycoprotein (A1BG) in human serum/plasma
  • MSMB interact with cysteine-rich secretory protein 3 (CRISP3) in seminal plasma
  • CRISP3 is a direct target of ERG that is strongly overexpressed in Prostate carcinoma with the TMPRSS2-ERG fusion gene (
  • MSMB bind human CRISP3 (cysteine-rich secretory protein 3) with very high affinity
  • CRISP3 binds specifically and with high affinity to MSMB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Sjogren syndrome
    tumoral     --over  
    in prostate cancer compared with normal prostate tissue
    tumoral     --over  
    strongly overexpressed in Prostate cancer with the TMPRSS2-ERG fusion gene (
    tumoral     --over  
    inprostate cancer with poor prognosis that could be due to its role in cell invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS