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FLASH GENE

Symbol

CRHR2

contributors: mct - updated : 20-03-2014

HGNC name	corticotropin releasing hormone receptor 2
HGNC id	2358

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p14.3      Physical location : 30.692.862 - 30.722.140
Synonym symbol(s)	CRF2, CRFR2, CRF-RB, HM-CRF

DNA

TYPE	functioning gene
STRUCTURE	48.16 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	pter - D7S623 - D7S529 - D7S516 - D7S632 - CRHR2 - D7S690 - D7S484 - cen
Authors	Meyer (97)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001202475 13 - 2904 NP_001189404 - 438 - 2011 21338628 CRHR2beta complex interplay between the signaling molecules that allow "fine-tuning" of CRH-R2beta functional responses and regulate signal integration NM_001202481 14 - 3131 NP_001189410 - 397 - 2011 21338628 CRHR2 gamma NM_001202482 12 - 2995 NP_001189411 - 410 - 2011 21338628 CRHR2 isoform desQ NM_001883 12 - 2998 "NP_001874 - 411 - 2011 21338628 CRHR2 alpha NM_001202483 - - 3109 NP_001189412 - 387 - 2011 21338628 CRHR2 isoform D

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Nervous nerve         Reproductive female system uterus cervix       male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal pseudo signal peptide that is unable to mediate targeting of the nascent chain to the endoplasmic reticulum membrane during early receptor biogenesis

HOMOLOGY

Homologene

FAMILY

G protein coupled, k1 secretin family

CATEGORY

signaling hormone , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	receptor for corticotropin releasing factor
	may be playing a central anxiolytic role at least time in mice
	coupling with Gs alpha protein and activating adenylate cyclase
	functioning as a local negative regulator of glucose uptake in skeletal muscle and encouraging exploration of the possibility that suppression of the UCN 2/CRHR2 pathway may provide benefits in insulin-resistant states such as type 2 diabetes
	play a facilitatory role in the non-clathrin-, non-caveolae-mediated endocytosis and intracellular signal transduction of urocortin (Tu 2007)
	CRHR2-positive neurons in the posterior medial amygdala are involved in the neural response to social defeat
	activation of CRHR2 inhibits P-currents in Purkinje neurons via G(o)alpha-dependent PLC/PKCepsilon pathway, which might contribute to its physiological functions in the cerebellum
	its activation could inhibit MAPK8 and AKT1 phosphorylation to suppress the secretion of VEGFA in small cell lung carcinoma cells
	novel role for UCN3 and CRHR2 related to the processing of social cues and to the establishment of social memories
	CRHR1 and CRHR2 differentially modulate the dendritic growth of hippocampal neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to urocortin I, II and III
	interacting with HPGD (mediate divergent effects on PGDH expression, and this may provide a precise regulation of PGs levels from chorion to myometrium during pregnancy)
	CRHR2 activation decrease DPYSL4 expression in hippocampal neurons via a mechanism that is dependent on PLC/PKC signaling pathways
	although not amidated, UCN2 prohormone purified from overexpressing lines activated CRHR2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS