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FLASH GENE

Symbol

CRHBP

contributors: mct - updated : 29-03-2008

HGNC name	corticotropin releasing hormone binding protein
HGNC id	2356

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q11.2-q13.3      Physical location : 76.248.679 - 76.265.298
Synonym symbol(s)	CRF-BP, CRFBP

DNA

TYPE	functioning gene
STRUCTURE	16.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 - 1854 - 322 - Van Den Eede (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Reproductive female system placenta     highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders
	may play a role in cervical ripening

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binds both CRH and urocortin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS