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FLASH GENE
Symbol CRHBP contributors: mct - updated : 29-03-2008
HGNC name corticotropin releasing hormone binding protein
HGNC id 2356
Location 5q11.2-q13.3      Physical location : 76.248.679 - 76.265.298
Synonym symbol(s) CRF-BP, CRFBP
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1854 - 322 - Van Den Eede (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Reproductivefemale systemplacenta  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders
  • may play a role in cervical ripening
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds both CRH and urocortin
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS