DNA associated
, transcription factor
, tumor suppressor
SUBCELLULAR LOCALIZATION
intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
some isoforms (with a Gln-rich domain) function as activators and some (without the Gln-rich domains) as repressors of transcription
playing a key role within the hypothalamus-pituitary-gonadal axis, involved in spermiogenesis
cAMP inducible transcriptional repressor involved in the survival of neurons and in inhibition of neuronal suicide
involved in regulating gene expression in haploid spermatids
involved in the modulation of myometrial activity during pregnancy and parturition
role of CREB1 and CREM in stimulus-dependent transcription and neuronal homeostasis
potential part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress
activator of gene transcription, competing, for the same DNA response element, with NR6A1 that suppresses gene transcription
component of the cAMP-mediated signal transduction during the spermatogenic cycle, playins a role in spermatid maturation
competes with CREB and AP1 for binding to the cathelicidin promoter and represses transcription and thus is involved in the innate hoste defense
plays an important role in regulating the neuroendocrine system and the circadian rythm
may be an important negative regulator of costimulation and APC-dependent T cell function
may be a tumor suppressor in leukemia
involvement of CREM in the lineage determination of effector memory CD4+ T cells, where it mediates epigenetic remodeling of the IL2 gene through the recruitment of DNMT3
potential role for CREM in chromatin remodeling of IL2 and IL17A and an enrichment of effector memory CD4+ T cells in SLE patients
CELLULAR PROCESS
nucleotide, transcription
PHYSIOLOGICAL PROCESS
development
, immunity/defense
PATHWAY
metabolism
signaling
signal transduction
a component
CREM–FHL5 complex mediates the expression of many post-meiotic genes that are essential for normal spermatogenesis, thus providing a tissue-specific modulation mechanism for CREM transcription activity
interacting with CREBBP (CBP) after phosphorylation of Ser117 in the transactivation domain
binding to NR6A1 via its DNA binding domain
interacting with FHL5
CRH interacting with CREM (endogenous CREM formation is required for termination of CRH transcription)(
CREM mediates epigenetic remodeling of the IL2 and IL17A gene during T-cell differentiation in favor of effector memory T cells in health and disease
C-terminus (Yang 2009)
DAZAP1 regulates the splicing of CREM, CRISP2 and POT1 transcripts
cell & other
REGULATION
activated by
mainly activated by its coactivator FHL5
protein kinase A-mediated phosphorylation
induced by
cAMP
Other
regulated in a circadian manner in the pineal gland
regulated by SFRS5 (regulates the splicing of CREM via its interactions with multiple exon splicing enhancers motifs present in the alternatively exons of CREM)
stimulated by phosphorylation
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
Type
Gene Modification
Chromosome rearrangement
Protein expression
Protein Function
tumoral
--low
down-regulated in the majority of chilhood leukemias
constitutional
--over
in T cells from patients with systemic lupus erythematosus (SLE)
