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FLASH GENE
Symbol CREBZF contributors: mct - updated : 22-09-2012
HGNC name CREB/ATF bZIP transcription factor
HGNC id 24905
Location 11q14.1      Physical location : 85.368.607 - 85.376.182
Synonym name
  • Zhangfei
  • host cell factor-binding transcription factor Zhangfei
  • SHP-interacting leucine zipper protein
  • HCF-binding transcription factor Zhangfei
  • Synonym symbol(s) ZF, SMILE, FLJ94018
    DNA
    TYPE functioning gene
    STRUCTURE 7.30 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 7304 - 354 - Xie (2009)
  • SMILE-L
  • entire N-terminus of NR0B2 and the middle region of SMILE-L are involved in this interaction
  • - initiation site - - - - Xie (2009)
    regulate the inhibition of ER transactivation by NR0B2 in a cell-type-specific manner and act as a novel transcriptional co-regulator in ER signalling
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Digestiveintestinelarge intestinecolon predominantly
    Lymphoid/Immunelymph node   highly
     thymus    
    Reproductivefemale systemovary   
     female systemuterus   
     male systemprostate   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic domain
  • a leucine zipper of 6 heptad leucine repeats
  • a conserved 6-amino acid spacer
  • a bZIP domain
  • the N-terminal acidic region is an activation domain
  • HOMOLOGY
    interspecies homolog to murine Crebzf (84.3pc)
    Homologene
    FAMILY
  • bZIP family
  • ATF/CREB family of transcription factors
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibits herpes simplex virus replication (Akhova 2005)
  • activating the TrkA promoter and inducing the expression of endogenous TrkA (Valderrama 2008)
  • inducing the expression of TrkA in medulloblastoma cells and causing their differenciation or apoptosis (Valderrama 2009)
  • inhibits GR, CAR and HNF4 alpha-mediated transactivation, corepressor of nuclear receptors via competition with coactivators and the recruitment of HDACs (Xie 2009)
  • orphan nuclear receptor NR0B2-interacting protein, regulating NR0B2-repressed estrogen receptor transactivation (Xie 2009)
  • cooperates synergistically with HEY1 to enhance TP53 transcriptional activity
  • CREBZF may participate in the modulation of p53 tumor suppressor function
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • cellular binding partner of CREB2, enhancing binding to the cAMP response element and augmenting activation of a CRE reporter by ATF4 in response to MEK1 activation (Hogan 2006)
  • CREBZF inhibits the function of BMP6 by interacting with SMAD1, SMAD5, SMAD9
  • functional interaction between CREBZF and the tumor suppressor TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS