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FLASH GENE
Symbol CREB3L4 contributors: mct - updated : 23-12-2013
HGNC name cAMP responsive element binding protein 3-like 4
HGNC id 18854
Location 1q21.3      Physical location : 153.940.396 - 153.946.832
Synonym name
  • androgen-induced basic leucine zipper
  • cAMP responsive element binding protein 1
  • transcript induced in spermiogenesis protein 40
  • attaching to CRE-like 1
  • Synonym symbol(s) JAL, ATCE1, AIbZIP, CREB3, CREB4, JAL, hJAL, RP11-422P24.8
    DNA
    TYPE functioning gene
    STRUCTURE 6.44 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1747 - 395 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pharynx   highly
     stomach   highly
    Nervousnervespinal nervesciatic  
    Reproductivemale systemprostate  highly
     male systemtestis   
    Visualeyelacrimal gland   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text present throughout development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal activation domain
  • a central bZIP domain
  • a predicted transmembrane domain
  • an adjacent cleavage site for the Golgi protease S1P, with conserved features which indicate that it represents a specific subclass of S1P sites
  • a C terminal transmembrane domain
  • HOMOLOGY
    interspecies ortholog to murine Creb3l4
    ortholog to rattus creb3l4
    Homologene
    FAMILY
  • BZIP family
  • CREB/ATF family transcription factor
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • transcriptional activator
  • binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes BBF2
  • involved in regulation of transcription, DNA-dependent
  • may be playing an important role in prostate cancer and in androgen receptor signaling in prostate cells
  • probable targets for the amplification mechanism and may therefore be involved, together or separately, in the development or progression of Hepatocellular carcinoma (Inagaki 2008)
  • ER-resident transmembrane transcription factor that is structurally similar to CREB3L1
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CREB3L4 and CREB3L1 may form a heterodimer that promotes the expression of target genes required for the differentiation of goblet cells
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cleaved in a site-specific manner in response to brefeldin A disruption of the Golgi or by coexpression with S1P but only after deletion or substitution of its C-terminal lumenal domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by androgens in prostate tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS