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FLASH GENE
Symbol CREB3 contributors: mct - updated : 13-12-2015
HGNC name cAMP responsive element binding protein 3
HGNC id 2347
Location 9p13.3      Physical location : 35.732.316 - 35.737.004
Synonym name
  • luman
  • cAMP responsive element binding protein 3 (luman)
  • cyclic AMP response element (CRE)-binding protein/activating transcription factor 1
  • transcription factor LZIP-alpha
  • leucine zipper protein
  • Synonym symbol(s) LZIP, LUMAN, MGC15333, MGC19782, sLZIP
    DNA
    TYPE functioning gene
    STRUCTURE 4.69 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure promoter has potential binding sites for transcription factors involved in inflammatory processes and regulation of the immune system, including nuclear factor B (NF-B), nuclear factor of activated T-cells, specific protein-1 (Sp-1), and activator protein-2 (AP-2)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1868 - 371 - -
    - - - - 345 . mainly localized in the nucleus 2009 19779205
  • contains a deleted putative transmembrane domain (amino acids 229–245) of CREB3
  • functions potentially as a negative regulator in glucocorticoid-induced transcriptional activation of GR by recruitment and activation of HDACs
  • induces expression of MMP9 and regulates its promoter activity by binding directly to the CRE region of the MMP9 promoter
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal activation domain
  • a basic DNA binding domain
  • a long leucine zipper and a tetra peptide motif DEHXY
  • a bZip domain, a predicted transmembrane domain and an adjacent cleavage site for the Golgi protease S1P, with conserved features which indicate that it represents a specific subclass of S1P sites
  • HOMOLOGY
    interspecies homolog to murine Creb3
    Homologene
    FAMILY
  • bZIP family
  • ATF subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • endoplasmic reticulum (ER)-bound cellular transcription factor
  • located in the cytoplasm
  • basic FUNCTION
  • regulator of cell proliferation
  • can bind and activate transcription from the consensus unfolded protein response element (UPRE)
  • may be playing a role in ER stress-associated protein degradation and being a converging point for various signaling pathways channeling through the ER
  • involved in the regulation of cell growth by binding to the host cell factor, which is involved in cell proliferation and may serves a novel cellular tumor suppressor function that is targeted by the hepatitis C virus core protein
  • potent activator of monocyte mobility
  • endoplasmic reticulum (ER) membrane-bound transcription factor which is believed to undergo regulated intramembrane proteolysis in response to cellular cues
  • factor that plays a role in ERAD and a converging point for various signaling pathways channeling through the ER
  • functions as a positive regulator in the NF-kappaB activation pathway that is triggered by CCL15 without affecting the transcriptional activation of NF-kappaB induced by other CCR1-dependent chemokines
  • implicated in the mammalian unfolded protein response (UPR), as well as herpes simplex virus reactivation from latency in sensory neurons
  • regulates expression of chemokine receptors that are involved in monocyte migration
  • enhanced both the migration and invasion of cervical cancer cells
  • CREB3, originally identified through its interaction with a cell cycle regulator HCFC1, is an endoplasmic reticulum membrane-bound transcription factor that is involved in the unfolded protein response
  • is a key regulator of NR3C1-mediated signaling and modulates hypothalamic-pituitary-adrenal axis (HPA) reactivity
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex CREB3/TM7SF4 is a novel regulatory circuit in dendritic cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HCFC1 by the tetra peptide motif o/CREB3
  • KLHDC2
  • associates with CC chemokine receptor 1 (CCR1) (this protein-protein interaction should play an important role in leukocyte cell mobility)
  • binds to CCR1 and this interaction participates in regulation of CCL15-dependent cell migration without affecting the chemotactic activities of other CC chemokines that bind to CCR1
  • regulate leukotactin-1 (CCL15)-dependent cell migration without affecting the chemotactic activities of other CC chemokines that bind to CCR1
  • binds with ZF only when in combination with HCFC1
  • interacting with HERPUD1 (necessary for the full activation of HERPUD1 during the ER stress response)
  • interacts with LRF through itsleucine zipper region, interaction promoting CREB3 degradation
  • physically interacting with TM7SF4 in the endoplasmic reticulum
  • HDAC3-interacting protein
  • bind to the CRE element in the CXCR4 promoter and to activate the transcription of the CXCR4 gene by causing dissociation of HDAC3
  • plays a critical role in MMP9 expression and is probably involved in invasion and metastasis of cervical cancer
  • APOA4 is a true target gene of CREB3 in bone marrow-derived DCs (BMDCs)
  • COPS5 is a novel binding partner of CREB3 which negatively regulates the activity of Luman by promoting its degradation
  • CREB3 was identified as a transcriptional regulator of upregulated ER-Golgi trafficking genes ARF4, COPB1, and USO1, and silencing of these genes attenuated lung colonization in breast cancer
  • cell & other
    REGULATION
    Other inactivated by hepatites C virus core protein potentiating cellular transformation
    regulated by HCFC1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS