basic FUNCTION
| inducing apoptosis via death domain receptors (death receptor adaptor protein) |
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coupling CASP2 to the Fas L/TNF receptor interacting protein RIP |
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death receptor adaptor protein |
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PIDD with CRADD, is implicated in the activation of pro-caspase-2 in a high molecular weight complex called the PIDDosome during apoptosis induction after DNA damage |
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novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists |
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implicated in DNA-damage-induced apoptosis as well as in tumorigenesis ) |
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is a critical component in type I IFN production |
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potential role for CRADD/CASP2 signaling in development of the human cerebral cortex |
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role for CRADD/CASP2 signaling in synaptic plasticity and cortical architecture during mammalian brain development |