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FLASH GENE
Symbol CRADD contributors: npt/mct - updated : 15-11-2013
HGNC name CASP2 and RIPK1 domain containing adaptor with death domain
HGNC id 2340
Corresponding disease
CRADALI CRADD-Associated Lissencephaly
MRT34 mental retardation, autosomal recessive 34
Location 12q22      Physical location : 94.071.150 - 94.244.529
Synonym name
  • death domain-containing protein CRADD
  • caspase and RIP adapter with death domain
  • RIP-associated protein with a death domain
  • death adaptor molecule RAIDD
  • RIP-associated ICH1/CED3-homologous protein with death domain
  • Synonym symbol(s) RAIDD, MGC9163
    DNA
    TYPE functioning gene
    STRUCTURE 217.50 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D12S327 - CRADD - D12S362 - HAL HAL - D12S1657 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1201 22 199 - 2000 10713730
    3 - 1197 - 121 - 2000 10713730
    3 - 654 - 115 - 2000 10713730
    3 - 1415 - 199 - 2000 10713730
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunelymph node    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal domain highly homolog of two ICE1/CED3 members CASP2 and CASP3, N-terminal caspase-recruitment domain (CARD)that binds with CASP2 to induce CASP2 activity
  • a N terminal DEATH domain that binds to the homologous domain of RIP a serine/threonine kinase component of the death pathway
  • HOMOLOGY
    interspecies homolog to murine Cradd
    homolog to C.elegans f07d10.7
    Homologene
    FAMILY
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • inducing apoptosis via death domain receptors (death receptor adaptor protein)
  • coupling CASP2 to the Fas L/TNF receptor interacting protein RIP
  • death receptor adaptor protein
  • PIDD with CRADD, is implicated in the activation of pro-caspase-2 in a high molecular weight complex called the PIDDosome during apoptosis induction after DNA damage
  • novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists
  • implicated in DNA-damage-induced apoptosis as well as in tumorigenesis )
  • is a critical component in type I IFN production
  • potential role for CRADD/CASP2 signaling in development of the human cerebral cortex
  • role for CRADD/CASP2 signaling in synaptic plasticity and cortical architecture during mammalian brain development
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PIDDosome, which is an oligomeric signaling complex composed of PIDD1, CRADD and CASP2, can induce proximity-based dimerization and activation of CASP2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RIP
  • interacts with procaspase-2 in a CARD-dependent manner and mediate the recruitment of caspase-2 to the tumour necrosis factor receptor 1 (TNFR1)
  • caspase-2-dependent execution of neurons requires CRADD, but not PIDD
  • functions as a dual adaptor and is a constituent of different multi-protein complexes implicated in the regulation of inflammation and cell death
  • adaptor molecule CRADD coordinates IKBKE and IRF7 interaction to ensure efficient expression of type I interferon
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRT34 , CRADALI
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in multidrug resistant cancer cell lines could possibly reverse drug resistant phenotypes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS