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FLASH GENE
Symbol CRABP1 contributors: mct/npt - updated : 19-05-2010
HGNC name cellular retinoic acid binding protein 1
HGNC id 2338
Location 15q25.1      Physical location : 78.632.665 - 78.640.572
Synonym symbol(s) CRABP, RBP5, RET3, CRABP-I, CRABPI
DNA
TYPE functioning gene
STRUCTURE 7.91 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure a consensus site, within an intron, 5 kb downstream from the promoter, which is implicated in regulation of retinoid signaling, and in PLZF-mediated repression
MAPPING cloned Y linked   status confirmed
Map cen - (breakpoint in acute promyelocytic leukemia APL ) - CRABP1 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 782 - 137 - Flagiello (1997)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestivemouth   moderately
Endocrineneuroendocrinepituitary  moderately
Lymphoid/Immunespleen   moderately
Reproductivefemale systemovary  highly
Skin/Tegumentskin   lowly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   lowly
Epithelialbarrier/lining  lowly
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period embryo, neonatal
Text skin, embryonic tissue
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a single eight-stranded continiously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site
  • HOMOLOGY
    interspecies homolog to rattus Crabp1 (99.27 pc)
    homolog to murine Crabp1 (99.27 pc)
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY signaling , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in retinoic acid-mediated differentiation and proliferation processes
  • having a tumor-suppressor function in esophageal epithelium, and its epigenetic silencing may play a pivotal role during esophageal carcinogenesis
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text transporter of small hydrophobic molecules
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by during chondrogenesis
    T3 (repression of CRABP1 requires receptor interacting protein 140 (NRIP1) (Park 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    renal cell carcinoma
    tumoral     --low  
    hypermethylation associated with low expression in papillary thyroid carcinoma and in colorectal tumor development
    tumoral     --over  
    contributing to retinoid resistance, in RARA-ZBTB16 acute myeloid leukemia phenotype
    tumoral     --low  
    by methylation-associated silencing in esophageal squamous-cell carcinoma (Tanaka 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene elevated level of CRABPI in the CSF of patients with Moyamoçya disease
    Marker
    Therapy target
    ANIMAL & CELL MODELS