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FLASH GENE
Symbol CPZ contributors: mct - updated : 09-01-2013
HGNC name carboxypeptidase Z
HGNC id 2333
Location 4p16.1      Physical location : 8.594.434 - 8.621.486
Synonym name metallocarboxypeptidase
Synonym symbol(s) MGC99682
EC.number 3.4.17.-
DNA
TYPE functioning gene
STRUCTURE 27.10 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391618 4 hypothetical gene supported by NM_003875 FLJ20356 HTRA3 4p16.1 serine protease HTRA3 ACOX3 4p15.3 acyl-Coenzyme A oxidase 3, pristanoyl FLJ35725 4p16.1 hypothetical protein FLJ35725 FLJ12891 4p16.1 hypothetical protein FLJ12891 GPR78 4p16.1 G protein-coupled receptor 78 CPZ 4p16 carboxypeptidase Z LOC391619 4 similar to ubiquitin-specific protease 17-like protein LOC391620 4 similar to ubiquitin-specific protease 17-like protein LOC391621 4 similar to ubiquitin-specific protease 17-like protein LOC391622 4 similar to ubiquitin-specific protease 17-like protein LOC391623 4 similar to ubiquitin-specific protease 17-like protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2292 73.5 652 - 1997 9099699
10 - 2259 71 641 - 1997 9099699
11 - 2555 58.4 515 - 1997 9099699
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 salivary gland    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandular  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide-like sequence
  • a carboxypeptidase domain
  • a cysteine-rich domain (CRD) similar to the CRD found in the frizzled family of Wnt receptors
  • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to CPE
    Homologene
    FAMILY
  • metallocarboxypeptidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • removes C-terminal basic AAs, particularly arginine residues, from proteins
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    text cleaving basic aminoacids of the C terminus of peptides
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • thyroid hormone may regulate terminal differentiation of growth plate chondrocytes in part by modulating Wnt signaling pathways through the induction of CPZ and subsequent CPZ-enhanced activation of WNT4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS