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FLASH GENE
Symbol CPSF6 contributors: mct - updated : 03-03-2020
HGNC name cleavage and polyadenylation specific factor 6, 68kDa
HGNC id 13871
Location 12q15      Physical location : 69.633.316 - 69.668.137
Synonym name
  • mammalian cleavage factor I
  • pre-mRNA cleavage factor Im, 68kD subunit
  • CPSF 68 kDa subunit
  • protein HPBRII-4/7
    • Synonym symbol(s) CFIM, HPBRII-4, HPBRII-7, CFIM68
    DNA
    TYPE functioning gene
    STRUCTURE 34.82 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6630 59 551 - 2019 30916345
    11 - 6695 - 588 - 2019 30916345
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemuterus  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • organization reminiscent of spliceosomal SR proteins
    • HOMOLOGY
    Homologene
    FAMILY
  • RRM CPSF6/7 family
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • in addition to paraspeckles, accumulates in structures that partially overlap with nuclear speckles
  • shuttles between the nucleus and the cytoplasm in a transcription-dependent manner
    • basic FUNCTION
  • 3' processing of pre mRNA precursors, early step facilitating the recruitement of other processing factors
  • essential factor that is required for the first step in pre-mRNA 3' end processing
  • novel function for the pre-mRNA 3' end processing factor CPSF6 in mRNA export
  • not only plays a general role in 3'-end processing but also plays a regulatory role in poly(A) site selection
  • regulates global alternative polyadenylation (APA) by specifically binding and activating enhancer-containing poly(A) sites (PASs)
  • NUDT21 and serine/arginine-like protein CPSF6, regulates alternative polyadenylation (APA)
  • is a critical host factor, that directly interacts with Bocavirus 1 NP1 Protein, mediates the nuclear import of NP1, and plays a role in the maturation of capsid protein-encoding mRNAs in the nucleus
    • CELLULAR PROCESS nucleotide, transcription, maturation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text polyadenylation
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with other CPSf,poly (A) ribonuclease (PARN) STF3 (cleavage stimulation factor 3)
    • INTERACTION
    DNA
    RNA binding to the AAUAA motif of the pre mRNA, upstream the cleavage site
    small molecule
    protein
  • interaction with U2AF2 in the functional coordination of splicing and 3' end processing
  • inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    to FGFR1, in t(8;12)(p11;q15) and the 8p11 myeloproliferative syndrome
    tumoral fusion      
    with RARG, RARG-CPSF6 fusion, in a patient with AML that appeared to be typical acute promyelocytic leukemia (APL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    is a molecular target with clinical relevance for prognosis and therapy in breast cancer
    ANIMAL & CELL MODELS