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FLASH GENE
Symbol CPSF3 contributors: mct/npt/pgu - updated : 29-08-2013
HGNC name cleavage and polyadenylation specific factor 3, 73kDa
HGNC id 2326
Location 2p25.1      Physical location : 9.563.867 - 9.613.227
Synonym name
  • CPSF 73 kDa subunit
  • mRNA 3'-end-processing endonuclease CPSF-73
  • Synonym symbol(s) CPSF, CPSF73, YSH1, CPSF-73
    EC.number 3.1.27.-
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 49.57 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC129607 2p25.2 hypothetical protein LOC129607 cig5 2p25.2 viperin RNF144 2p25 ring finger protein 144 LOC129614 2p25.2 similar to acidic integral membrane protein LOC391350 2 similar to ENSANGP00000014942 ID2 2p25 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein KIDINS220 2p24 likely homolog of rat kinase D-interacting substance of 220 kDa LOC129642 2p25.2 hypothetical protein BC016005 DDEF2 2p24 development and differentiation enhancing factor 2 ITGB1BP1 2p25.2 integrin beta 1 binding protein 1 CPSF3 2pter-p25 cleavage and polyadenylation specific factor 3, 73kDa LOC285148 2p25.2 hypothetical protein LOC285148 ADAM17 2p25 a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) YWHAQ 2p25 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide TAF1B 2p25 TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa TFCP2L2 2p25.1 transcription factor CP2-like 2 TIEG2 2p25 TGFB inducible early growth response 2 RRM2 2p24 ribonucleotide reductase M2 polypeptide FLJ25102 2p25.1 hypothetical protein FLJ25102 HPCAL1 2p25.1 hippocalcin-like 1 ODC1 2p25 ornithine decarboxylase 1 LOC130063 2p25.1 hypothetical gene LOC130063 FLJ14075 2p25.1 hypothetical protein FLJ14075 ATP6V1C2 2p25.1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2 P5 2p25.1 protein disulfide isomerase-related protein LOC388924 2 LOC388924 KCNF1 2p25 potassium voltage-gated channel, subfamily F, member 1 FLJ33534 2p25.1 hypothetical protein FLJ33534 LOC391351 2 similar to RPL6 protein FLJ25143 2p25.1 hypothetical protein FLJ25143 MGC33602 ROCK2 2p24 Rho-associated, coiled-coil containing protein kinase 2 LOC391352 2 similar to peptidyl-Pro cis trans isomerase E2F6 22q11.2 E2F transcription factor 6 GREB1 2p25.1 E2F transcription factor 6 NTSR2 2p25.1 neurotensin receptor 2 LPIN1 2p25.1 lipin 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2401 77.3 684 - 2009 19136632
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a metallo-beta-lactamase domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Yst,subunit of the polyadenylation factor PFI
    Homologene
    FAMILY
  • metallo-beta-lactamase superfamily
  • RNA-metabolizing metallo-beta-lactamase-like family
  • CPSF3 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in endonucleolytic cleavage and polyadenylation of mRNA
  • pre-mRNA 3'-end-processing endonuclease
  • endonuclease and 5'-3' exonuclease activities in histone-pre-mRNA processing
  • important regulatory protein that represses the basal transcriptional activity of the HIV-1 LTR promoter
  • CPSF3 and CPSF2 act together in the process of maturation of eukaryotic pre-messenger RNAs, similar to other members of the MBL family, RNases Z and J, which function as homodimers
  • catalyzing the endonucleolytic cleavage
  • catalysing the 3prime-end cleavage of histone pre-mRNAs, requiring the interaction of two U7 snRNP-associated proteins, CASP8AP2 and LSM11
  • can be recruited to histone pre-mRNA largely in a manner independent of CASP8AP2, possibly by a separate domain in LSM11
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text polyadenylation
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CPSF1, 2, 4 poly (A) ribonuclease (PARN)) and CSTF3 (cleavage stimulation factor 3)
  • an essential component for converting heteronuclear RNA to mRNA
  • INTERACTION
    DNA
    RNA binding to the AAUAA motif of the pre mRNA, upstream the cleavage site
    small molecule
    protein
  • binds with high affinity to the SCARA3 C terminus (induced redistribution of CPSF3 from the nucleus to the cytoplasm )
  • associates with CSTF3(are required for the maturation of mRNA 3 prime ends in the cell nucleus, with CDC73)
  • TUT1 binds to the RNA, recruits the CPSF complex to the 3 prime-end of pre-mRNA and then defines cleavage by CPSF3 and subsequent polyadenylation of its target mRNAs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS