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FLASH GENE
Symbol CPSF2 contributors: npt/mct - updated : 19/11/2008
HGNC name cleavage and polyadenylation specific factor 2, 100kDa
HGNC id 2325
Location 14q32.12      Physical location : 92.588.328 - 92.630.543
Synonym name CPSF 100 kDa subunit
Synonym symbol(s) KIAA1367, CPSF100
DNA
TYPE like-sequence
STRUCTURE 42.25 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
RPS18P2 14 ribosomal protein S18 pseudogene 2 LOC283588 14q32.12 hypothetical protein LOC283588 RPS6KA5 14q31-q32.1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 C14orf159 14q32.12 chromosome 14 open reading frame 159 GPR68 14q31 G protein-coupled receptor 68 KIAA1509 14q32.12 KIAA1509 LOC388005 14 similar to RIKEN cDNA 0610010D24 KIAA2010 14q32.12 KIAA2010 C14orf161 14q32.12 chromosome 14 open reading frame 161 MTAC2D1 14q32.12 membrane targeting (tandem) C2 domain containing 1 FBLN5 14q32.1 fibulin 5 TRIP11 14q31-q32 thyroid hormone receptor interactor 11 PTMAP7 14 prothymosin, alpha pseudogene 7 MJD 14q24.4-q32.1 Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) NDUFB1 14q31.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa CPSF2 14q31.3 cleavage and polyadenylation specific factor 2, 100kDa SLC24A4 14q32.12-q32.13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 RIN3 14q32.13 Ras and Rab interactor 3 LGMN 14q32.1 legumain GOLGA5 14q24.3-q31.3 golgi autoantigen, golgin subfamily a, 5 CHGA 14q32 chromogranin A (parathyroid secretory protein 1) ITPK1 14q31 inositol 1,3,4-triphosphate 5/6 kinase CYB5P3 14q31-q32.1 cytochrome b-5 pseudogene 3 MOAP1 14q32 modulator of apoptosis 1 C14orf109 14q32.13 chromosome 14 open reading frame 109 C14orf142 14q32.13 chromosome 14 open reading frame 142 C14orf130 14q32.13 chromosome 14 open reading frame 130 RPL18AP1 14 ribosomal protein L18a pseudogene 1 RPL36AP4 14 ribosomal protein L36a pseudogene 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 5072 88 782 - 2000 11124543
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Respiratoryrespiratory tracttrachea  highly
 respiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
Homologene
FAMILY
  • metallo-beta-lactamase superfamily
  • RNA-metabolizing metallo-beta-lactamase-like family
  • CPSF2/YSH1 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • essential for maturation process
  • 3'processing of mRNAs precursors and subsequent polyadenylation
  • CPSF3 and CPSF2 act together in the process of maturation of eukaryotic pre-messenger RNAs, similar to other members of the MBL family, RNases Z and J, which function as homodimers
  • CELLULAR PROCESS nucleotide, transcription, maturation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text polyadenyaltion
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CPSF1,3,4,poly (A) ribonuclease (PARN) and CSTF3 (cleavage stimulation factor 3)
  • INTERACTION
    DNA
    RNA binding to the AAUAA motif of the pre mRNA, upstream the cleavage site
    small molecule other, binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS