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FLASH GENE
Symbol CPNE2 contributors: - updated : 22-12-2004
HGNC name copine II
HGNC id 2315
Location 16q13      Physical location : 57.126.509 - 57.181.876
Synonym symbol(s) CPN2, COPN2
DNA
TYPE functioning gene
STRUCTURE 55.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390733 16 similar to MTM MT1B 16q13 metallothionein 1B (functional) MT1F 16q13 metallothionein 1F (functional) MT1G 16q13 metallothionein 1G MT1H 16q13 metallothionein 1H MT1X 16q13 metallothionein 1X KIAA0095 16q13 metallothionein 1X SLC12A3 16q13 solute carrier family 12 (sodium/chloride transporters), member 3 HERPUD1 16q12.2-13 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 CETP 16q13 cholesteryl ester transfer protein, plasma NOD27 16q13 nucleotide-binding oligomerization domains 27 CPNE2 16q13 copine II NIP30 16q13 NEFA-interacting nuclear protein NIP30 KIAA1972 16q13 KIAA1972 protein TM4SF11 16q12-q13 transmembrane 4 superfamily member 11 (plasmolipin) BART1 CX3CL1 16q13 chemokine (C-X3-C motif) ligand 1 CCL22 16q13 chemokine (C-C motif) ligand 22 CCL17 16q13 chemokine (C-C motif) ligand 17 LOC57019 16q13-q21 hypothetical protein LOC57019 POLR2C 16q13-q21 polymerase (RNA) II (DNA directed) polypeptide C, 33kDa DOK4 16q13 docking protein 4 MGC10992 16q13 hypothetical protein LOC92922
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two Ca(2+)- and phospholipid-binding domains known as 'C2 domains'
  • and a C terminal region distantly to the A domain,one WWFA domain
  • HOMOLOGY
    Homologene
    FAMILY copine family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text secretory vesicle
    basic FUNCTION
  • calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking and in protein-protein interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • vesicular transport
  • membrane trafficking
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    phospholipid binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS