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FLASH GENE
Symbol CPN1 contributors: npt/ - updated : 07-10-2006
HGNC name carboxypeptidase N, polypeptide 1
HGNC id 2312
Location 10q24.31      Physical location : 101.802.064 - 101.841.642
Synonym name
  • kininase 1
  • carboxypeptidase N, polypeptide 1, 50kD
  • anaphylatoxin inactivator
  • arginine carboxypeptidase
  • carboxypeptidase N small subunit
  • Synonym symbol(s) CPNL, ACBP, CPN , FLJ40792, SCPN
    EC.number 3.4.17.3
    DNA
    TYPE functioning gene
    STRUCTURE 39.58 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1756 50 458 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • conjugated MetalloP
    mono polymer heteromer , tetramer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • zinc carboxypeptidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • cleaving basic amino acid residues from the C terminal of peptides such as kinins and anaphylatoxins catalytic subunit
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text protecting from potent vasoactive and inflammatory peptides
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • kinins, anaphylatoxins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS