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FLASH GENE
Symbol CPN1 contributors: npt/ - updated : 07-10-2006
HGNC name carboxypeptidase N, polypeptide 1
HGNC id 2312
Location 10q24.31      Physical location : 101.802.064 - 101.841.642
Synonym name
  • kininase 1
  • carboxypeptidase N, polypeptide 1, 50kD
  • anaphylatoxin inactivator
  • arginine carboxypeptidase
  • carboxypeptidase N small subunit
  • Synonym symbol(s) CPNL, ACBP, CPN , FLJ40792, SCPN
    EC.number 3.4.17.3
    DNA
    TYPE functioning gene
    STRUCTURE 39.58 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CNNM1 10q24.33 cyclin M1 GOT1 10q24 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) NKX2-3 10q24.33 NK2 transcription factor related, locus 3 (Drosophila) SLC25A28 10q24 solute carrier family 25, member 28 LALP1 10q23-q24 solute carrier family 25, member 28 COX15 10q24 COX15 homolog, cytochrome c oxidase assembly protein (yeast) CGI-32 10q24.31 CGI-32 protein ABCC2 10q24 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 KIAA1010 10q25.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 CPN1 10q24.31 carboxypeptidase N, polypeptide 1, 50kD KEO4 CHUK 10q24-q25 conserved helix-loop-helix ubiquitous kinase FLJ10998 10q24.31 hypothetical protein FLJ10998 MGC10120 10q24.31 hypothetical protein MGC10120 PKD2L1 10q24-q25 polycystic kidney disease 2-like 1 SCD 10q23-q24 stearoyl-CoA desaturase (delta-9-desaturase) LOC90271 10q24.31 hypothetical protein LOC90271 WNT8B 10q24 wingless-type MMTV integration site family, member 8B SEC31L2 10q24.32 SEC31-like 2 (S. cerevisiae) NDUFB8 10q23.2-q23.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa HIF1AN 10q24 hypoxia-inducible factor 1, alpha subunit inhibitor PAX2 10q22.1-q24.3 paired box gene 2 C10orf6 10q24.31 chromosome 10 open reading frame 6 SEMA4G 10q24.2 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G MRPL43 10q24.1-q24.3 mitochondrial ribosomal protein L43 PEO1 KIAA1813 10q24 KIAA1813 protein FLJ23209 10q24.32 hypothetical protein FLJ23209
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1756 50 458 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • conjugated MetalloP
    mono polymer heteromer , tetramer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • zinc carboxypeptidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • cleaving basic amino acid residues from the C terminal of peptides such as kinins and anaphylatoxins catalytic subunit
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text protecting from potent vasoactive and inflammatory peptides
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • kinins, anaphylatoxins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS