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FLASH GENE
Symbol CPM contributors: - updated : 02-05-2006
HGNC name carboxypeptidase M
HGNC id 2311
Location 12q15      Physical location : 69.244.957 - 69.357.020
Synonym name MAX-1 antigen
Synonym symbol(s) D12S1501
EC.number 3.4.17.12
DNA
TYPE functioning gene
STRUCTURE 75.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure an upstream promoter sequence containing several transcription factor binding sites
MAPPING cloned Y linked N status provisional
Physical map
HGT2 12q14.3 protein tyrosine phosphatase, receptor type, R TIP120A 12q14 protein tyrosine phosphatase, receptor type, R LOC390341 12 similar to nuclear localization signal containing protein deleted in Velo-Cardio-Facial syndrome DYRK2 12q14.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 LOC341333 12q14.3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) IFNG 12q14-q15 interferon, gamma IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056 CNOT2 12q13.2 CCR4-NOT transcription complex, subunit 2 KCNMB4 12q14.1-q15 potassium large conductance calcium-activated channel, subfamily M, beta member 4 LOC390342 12 similar to Gag-Pro-Pol-Env protein PTPRB 12q15 protein tyrosine phosphatase, receptor type, B PTPRR 12q13.2-q13.3 protein tyrosine phosphatase, receptor type, R
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 6706 50 443 - Kas
- - 6635 50 443 - Kas
- - 6651 - 443 - Reverter
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Reproductivefemale systemplacenta  highly
Urinarybladder   highly
 kidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • hydrophobic domains at the N and C termini
  • a conserved catalytic domain including six glycosylation sites
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION carboxypeptidase M cleaving basic C terminal amino acids in monocyte to macrophage differentiation
    CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • activating peptide hormones at local tissue sites, before or after binding to their ligands
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several tumor tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS