Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CPEB4 contributors: mct/pgu - updated : 23-06-2011
HGNC name cytoplasmic polyadenylation element binding protein 4
HGNC id 21747
Location 5q35.2      Physical location : 173.315.330 - 173.387.312
Synonym name CPE-binding protein 4
Synonym symbol(s) KIAA1673, CPE-BP4
DNA
TYPE functioning gene
STRUCTURE 71.98 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FGF18 5q34 fibroblast growth factor 18 FBXW1B 5q35.1 F-box and WD-40 domain protein 1B STK10 5q35.1 serine/threonine kinase 10 LOC285588 5q35.2 similar to RIKEN cDNA 1700007I06 DC-UbP 5q35.2 dendritic cell-derived ubiquitin-like protein KIAA1295 5q35.2 KIAA1295 protein LOC391849 5 similar to neuralized homolog LOC133539 5q35.2 similar to RIKEN cDNA 1810009O10 DUSP1 5q34 dual specificity phosphatase 1 KIAA1181 5q35.2 KIAA1181 protein LOC389344 5 LOC389344 RPL26L1 5q35.2 ribosomal protein L26-like 1 LOC285591 5q35.2 inorganic pyrophosphatase pseudogene ATP6V0E 5q35.3 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e LOC153222 5q35.2 adult retina protein BNIP1 5q33-q34 BCL2/adenovirus E1B 19kDa interacting protein 1 LOC391850 5 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) NKX2-5 5q34-q35.3 NK2 transcription factor related, locus 5 (Drosophila) STC2 5p14.2-q15 stanniocalcin 2 LOC389345 5 LOC389345 LOC91272 5q35.2 hypothetical protein BC007436 CPEB4 5q21 cytoplasmic polyadenylation element binding protein 4 HMP19 5q35.2 HMP19 protein GAPDL16 5q33.1-q35.3 glyceraldehyde-3-phosphate dehydrogenase-like 16 MSX2 5q35.1 msh homeo box homolog 2 (Drosophila) DRD1 5q35.1 dopamine receptor D1 SFXN1 5q35.3 sideroflexin 1 HRH2 5q35.3 histamine receptor H2 CPLX2 5q35.1-q35.3 complexin 2 LOC389346 5 similar to hypothetical protein THOC3 5q35.2-q35.3 THO complex 3 LOC391851 5 similar to olfactory receptor MOR126-1 LOC389347 5 similar to NY-REN-7 antigen LOC391852 5 similar to MGC68922 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 7769 - 729 - 2006 17024188
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 parathyroid   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motifs (RRM)
  • a Zn-finger structure
  • HOMOLOGY
    interspecies homolog to murine Cpeb4
    Homologene
    FAMILY
  • RRM CPEB family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in some forms of synaptic plasticity
  • regulates cytoplasmic polyadenylation of mRNAs as a trans factor in oogenesis and spermatogenesis
  • promotes polyadenylation-induced translation in oocytes and neurons
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • controlling translation with CPEB1, and thus regulating mitotic cell-cylce progression
  • CPEB1 and CPEB4 are differentially regulated by phase-specific kinases, generating the need of two sequential CPEB activities to sustain cytoplasmic polyadenylation during all the meiotic phases
  • regulates cytoplasmic polyadenylation and translation in germ cells and the brain
  • necessary for cell survival and becomes nuclear in response to focal ischemia and when cultured neurons are deprived of oxygen and glucose
  • RNA-binding protein that participates in translational control
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE)
    small molecule
    protein
  • interacting with CPEB1 (establishes a new meiotic circuit by activating the synthesis of CPEB4, which, in turn, compensates for the inactivation and degradation of CPEB1 by mediating cytoplasmic polyadenylation in the second meiotic division)
  • cell & other
    REGULATION
    activated by translationally activated by CPEB1 during meiotic maturation
    Other regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS