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FLASH GENE
Symbol CPEB4 contributors: mct/pgu - updated : 23-06-2011
HGNC name cytoplasmic polyadenylation element binding protein 4
HGNC id 21747
Location 5q35.2      Physical location : 173.315.330 - 173.387.312
Synonym name CPE-binding protein 4
Synonym symbol(s) KIAA1673, CPE-BP4
DNA
TYPE functioning gene
STRUCTURE 71.98 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 7769 - 729 - 2006 17024188
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 parathyroid   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motifs (RRM)
  • a Zn-finger structure
  • HOMOLOGY
    interspecies homolog to murine Cpeb4
    Homologene
    FAMILY
  • RRM CPEB family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in some forms of synaptic plasticity
  • regulates cytoplasmic polyadenylation of mRNAs as a trans factor in oogenesis and spermatogenesis
  • promotes polyadenylation-induced translation in oocytes and neurons
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • controlling translation with CPEB1, and thus regulating mitotic cell-cylce progression
  • CPEB1 and CPEB4 are differentially regulated by phase-specific kinases, generating the need of two sequential CPEB activities to sustain cytoplasmic polyadenylation during all the meiotic phases
  • regulates cytoplasmic polyadenylation and translation in germ cells and the brain
  • necessary for cell survival and becomes nuclear in response to focal ischemia and when cultured neurons are deprived of oxygen and glucose
  • RNA-binding protein that participates in translational control
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE)
    small molecule
    protein
  • interacting with CPEB1 (establishes a new meiotic circuit by activating the synthesis of CPEB4, which, in turn, compensates for the inactivation and degradation of CPEB1 by mediating cytoplasmic polyadenylation in the second meiotic division)
  • cell & other
    REGULATION
    activated by translationally activated by CPEB1 during meiotic maturation
    Other regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS