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Symbol CPEB3 contributors: mct/npt - updated : 23-06-2012
HGNC name cytoplasmic polyadenylation element binding protein 3
HGNC id 21746
Location 10q23.32      Physical location : 93.808.398 - 94.050.875
Synonym name
  • related to C elegans hypothetical 42.4kDa protein, C40H1.1
  • CPE-binding protein 3
  • Synonym symbol(s) KIAA0940, CPE-BP3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, gene in gene
    text an 81-nucleotide ribozyme contained in the intron 3
    STRUCTURE 242.48 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    PANK1 10q22.3-q23 pantothenate kinase 1 FLJ37201 10q23.32 hypothetical protein FLJ37201 MPHOSPH1 10q23.33 M-phase phosphoprotein 1 LOC119358 10q23.32 similar to Small nuclear ribonucleoprotein Sm D2 (snRNP core protein D2) (Sm-D2) HTR7 10q22-q24 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) RPP30 10q23.32-q23.33 ribonuclease P (30kD) ANKRD1 10q23.33 ankyrin repeat domain 1 (cardiac muscle) LOC387701 10 LOC387701 MGC34007 10q23.33 hypothetical protein MGC34007 MGC16202 10q23.33 hypothetical protein MGC16202 FLJ37306 10q23.32 hypothetical protein FLJ37306 LOC387702 10 similar to hypothetical protein FLJ25224 PPP1R3C 10q23-q24 protein phosphatase 1, regulatory (inhibitor) subunit 3C LOC389995 10 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) TNKS2 10q23.3 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 C10orf13 10q23.33 chromosome 10 open reading frame 13 BTAF1 10q22-q23 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae) CPEB3 10q23.33 cytoplasmic polyadenylation element binding protein 3 FLJ20445 10q23.33 hypothetical protein FLJ20445 LOC389996 10 similar to MAP/microtubule affinity-regulating kinase 2 isoform a; ELKL motif kinase 1; ELKL motif kinase IDE 10q24 insulin-degrading enzyme KIF11 10q24.1 kinesin family member 11 LOC283014 10q23.33 similar to eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic initiation factor 2-beta HHEX 10q24 hematopoietically expressed homeobox SEC15L1 10q23.33 SEC15-like 1 (S. cerevisiae) CYP26C1 10q23.33 cytochrome P450, family 26, subfamily C, polypeptide 1 CYP26A1 10q23-q24 cytochrome P450, family 26, subfamily A, polypeptide 1 LOC389997 10 similar to Saccharomyces cerevisiae Nip7p homolog LOC387703 10 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) LOC389998 10 similar to 60S ribosomal protein L17 (L23) FER1L3 10q23.3 fer-1-like 3, myoferlin (C. elegans) C10orf3 10q23.33 chromosome 10 open reading frame 3 GPR120 10q23.33 G protein-coupled receptor 120 RBP4 10q24 retinol binding protein 4, plasma PDE6C 10q24 phosphodiesterase 6C, cGMP-specific, cone, alpha prime C10orf4 10q23.33 chromosome 10 open reading frame 4 LGI1 10q24 leucine-rich, glioma inactivated 1 FLJ33990 10q23.33 hypothetical protein FLJ33990 PSMD4P2 10q23.33 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pseudogene 2 PLCE1 10q23 phospholipase C, epsilon 1 AD24 10q23.33 AD24 protein KIAA0608 10q23.33 KIAA0608 protein
    RNA
    TRANSCRIPTS type messenger
    text
  • two alternatively spliced transcripts produced by the use of an alternate untranslated first exons, one expressed in liver and testis, and the other expressed in brain
  • the self-cleaving ribozyme is structurally related to ribozymes from human hepatitis delta virus (HDV), a single-stranded RNA satellite virus for hepatitis B infection (Salehi-Ashtiani et al, 2006)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 5753 - 684 - 2006 16990549
    10 - 5877 76 698 - 2006 16990549
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   moderately
     stomach   highly
    Endocrinepancreas   highly
     thyroid   highly
    Reproductivemale systemprostate  moderately
    Respiratoryrespiratory tractlarynx  predominantly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text
  • potentially up-regulated in the retina during development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal glutamine-rich domain
  • two RRM (RNA recognition motif) domains
  • conserved nuclear export signals that are not present in CPEB
  • a C-terminal zinc finger domain, and RNA-binding domain of CPEB3 binds to the C-terminal unstructured region of TOB1
  • HOMOLOGY
    interspecies homolog to murine ApCPEB (98 pc)
    Homologene
    FAMILY
  • RRM CPEB family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • nucleocytoplasm-shuttling protein with predominant residence in the cytoplasm, whereas activation of NMDA receptors accumulates CPEB3 in the nucleus
  • nucleus-cytoplasm shuttling protein retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
  • CPEB3 and NEURL1 colocalize along the apical dendrites of adult CA1 neurons, in opposition to Synaptophysin
  • basic FUNCTION
  • involved in some forms of synaptic plasticity
  • promotes polyadenylation-induced translation in oocytes and neurons
  • role for CPEB3 in human episodic memory
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • RNA-binding protein that participates in translational control
  • sequence-specific translational regulatory protein
  • regulates translation in neurons, albeit probably not through polyadenylation
  • sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons (
  • has a novel function in the nucleus as to suppress STAT5B-dependent EGFR gene transcription
  • negatively regulates the expression of a target by accelerating deadenylation and decay of its mRNA, which it achieves by tethering to the mRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE)
    small molecule
    protein
  • EGFR, is a target gene transcriptionally activated by STAT5B and downregulated by CPEB3 in neurons (
  • TOB1 binds directly to CPEB3 (binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex)
  • NEURL and ubiquitin modulate CPEB3-dependent translation of GRIA1 and GRIA2
  • CAPN2 activated through NMDAR signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons (
  • cell & other
    REGULATION
    activated by Neuralized1, an E3 ubiquitin ligase
    Other regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS