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FLASH GENE
Symbol CPEB2 contributors: mct/npt - updated : 04/10/2008
HGNC name cytoplasmic polyadenylation element binding protein 2
HGNC id 21745
Location 4p15.33      Physical location : 15.004.297 - 15.071.776
Synonym name CPE-binding protein 2
Synonym symbol(s) MGC119575, MGC119576, MGC119577, CPE-BP2
DNA
TYPE functioning gene
STRUCTURE 66.25 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391634 4 similar to heat-shock protein hsp84 RAB28 4p16.1 RAB28, member RAS oncogene family BAPX1 4p16.1 bagpipe homeobox homolog 1 (Drosophila) LOC285548 4p16.1 hypothetical protein LOC285548 FLJ33215 4p16.1 hypothetical protein FLJ33215 LOC391635 4 similar to 60S ribosomal protein L21 LOC391636 4 similar to hepatocellular carcinoma-associated antigen 59 CPEB2 4p15.33 cytoplasmic polyadenylation element binding protein 2 C1QTNF7 4p15.3 C1q and tumor necrosis factor related protein 7 KIAA1345 4p15.33 KIAA1345 protein FBXL5 4p15.3-p15.2 F-box and leucine-rich repeat protein 5 LOC285550 4p15.33 hypothetical protein LOC285550 BST1 14q32.3 bone marrow stromal cell antigen 1 CD38 4p15 CD38 antigen (p45) HBP17 4p16-p15 CD38 antigen (p45) KSP37 4p16 Ksp37 protein PROM1 4p16.1-p15.2 prominin 1 FLJ90013 4p15.33 hypothetical protein FLJ90013 FLJ39653 4p15.33 hypothetical protein FLJ39653 LOC391637 4 similar to Zinc finger homeobox protein 1b (Smad interacting protein 1) (SMADIP1) (HRIHFB2411) LDB2 4p15 LIM domain binding 2
RNA
TRANSCRIPTS type messenger
text two alternatively spliced variants
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 5627 64 589 - Kurihara (2003)
this variant lacks an in-frame coding segment, as compared to variant A. The resulting isoform B lacks an internal segment
10 splicing 5537 61 64,9 - Kurihara (2003)
this variant encodes the longest isoform
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland highly
 male systemtestis   
Urinarykidney   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motifs
  • conserved nuclear export signals that are not present in CPEB
  • HOMOLOGY
    interspecies homolog to murine Cpeb2
    Homologene
    FAMILY
  • RRM CPEB family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text nucleus-cytoplasm shuttling protein retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity
    basic FUNCTION
  • regulating cytoplasmic polyadenylation of mRNA as a transfactor in oogenesis and spermatogenesis
  • involved in some forms of synaptic plasticity
  • regulate translation by binding to regulatory motifs of defined mRNA targets
  • RNA-binding protein that participates in translational control
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the cytoplasmic polyadenylation element (CPE)
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by endogenous miRNAs that co-regulate CPEB2, CPEB3 and CPEB4 transcripts
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS