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FLASH GENE
Symbol CPE contributors: mct - updated : 23-02-2015
HGNC name carboxypeptidase E
HGNC id 2303
Location 4q32.3      Physical location : 166.300.096 - 166.419.481
Synonym name
  • enkephalin convertase
  • prohormone-processing carboxypeptidase
  • Synonym symbol(s) CPH
    EC.number 3.4.17.10
    DNA
    TYPE functioning gene
    STRUCTURE 119.40 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure large first intron
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2460 50.8 476 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Cpe
    Homologene
    FAMILY
  • zinc carboxypeptidase family
  • peptidase M14 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    text secretory granules
    basic FUNCTION
  • carboxypeptidase E, involved in the trimming of paired basic residues at the C terminus of prohormone or neurotransmitters-derived peptides after endoprotease cleavage
  • regulated secretory pathway sorting receptor
  • may be a key molecule to regulate CNTNAP2 trafficking to the cell membrane
  • membrane-bound form functions as a sorting receptor of prohormones in the trans-Golgi network
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • insulin, POMC and others
  • Caspr2-interacting candidate protein
  • ABCF1, AKAP1, CPE, DOPEY1 and GOPC may be targeted specifically by the initiator CASP8 and CASP10 during the early stages of apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes
    Variant & Polymorphism SNP R283W
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mutated in the obese fat mouse