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FLASH GENE

Symbol

CPD

contributors: - updated : 09-07-2007

HGNC name	carboxypeptidase D
HGNC id	2301

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q11.2      Physical location : 28.705.983 - 28.795.699
Synonym symbol(s)	CPNL
EC.number	3.4.17.22

DNA

TYPE	functioning gene
STRUCTURE	89.00 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	several transcripts

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CPD - - 8025 180 1380 - O malley CPD-N - - - 160 - selectively expressed in several haematopoietic tumour cells O malley has an incomplete N-terminal domain I but intact domains II and III nuclear localization

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage
cell lines	hepatoma cells
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	B type membrane bound metallocarboxypeptidase comprising
	three tandem active site domains, three CP domains
	zinc peptide domain

conjugated

MetalloP

isoforms

Precursor

HOMOLOGY

interspecies	ortholog to duck gp180 (hepatitis virus-binding protein)
	ortholog to murine Cpd

Homologene

FAMILY

zinc carboxypeptidase family, peptidase M14 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
text	localizd in the TGN (trans-Golgi network)

basic FUNCTION

carboxypeptidase, involved in secretory pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 2 zinc ions per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS