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FLASH GENE
Symbol CPD contributors: - updated : 09-07-2007
HGNC name carboxypeptidase D
HGNC id 2301
Location 17q11.2      Physical location : 28.705.983 - 28.795.699
Synonym symbol(s) CPNL
EC.number 3.4.17.22
DNA
TYPE functioning gene
STRUCTURE 89.00 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status confirmed
Physical map
SEZ6 17q11.2 seizure related 6 homolog (mouse) LOC342659 17q11.2 similar to NADH-ubiquinone oxidoreductase 15 kDa subunit (Complex I-15 kDa) (CI-15 kDa) PIPOX 17q11.2 pipecolic acid oxidase TIAF1 17q11.1-q11.2 TGFB1-induced anti-apoptotic factor 1 LOC390783 17 hypothetical gene supported by U02680; NM_002822 CRYBA1 17q11.2-q12 crystallin, beta A1 182-FIP 17q11.2 82-kD FMRP Interacting Protein KIAA1361 17q11.2 serine/threonine protein kinase TAO1 homolog LOC116236 17q11.2 hypothetical protein LOC116236 LOC90313 17q11.2 hypothetical protein BC004507 GIT1 17p11.2 G protein-coupled receptor kinase-interactor 1 FLJ25555 17q11.2 hypothetical protein FLJ25555 FLJ14871 17q11.2 hypothetical protein FLJ14871 SSH2 17q11.2 slingshot 2 FLJ46247 17q11.2 FLJ46247 protein DKFZP434K1421 17q11.2 hypothetical protein DKFZp434K1421 SLC6A4 17q11.2 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 BLMH 17q11.2 bleomycin hydrolase LOC388364 17 similar to AWKS9372 CPD 17q11.2 carboxypeptidase D GOSR1 17q11.2 golgi SNAP receptor complex member 1 LOC390784 17 similar to Arachidonate 12-lipoxygenase, 12S-type (12-LOX) (Platelet-type lipoxygenase 12) LOC388365 17 LOC388365 DKFZP434O047 17q11.2 DKFZP434O047 protein LOC284089 17q11.2 similar to keratin 17 LOC388366 17 LOC388366 DKFZp667M2411 17q11.2 hypothetical protein DKFZp667M2411 LOC388367 17 similar to Joined to JAZF1 CRLF3 17q11.2 cytokine receptor-like factor 3 FLJ12735 17q11.2 cytokine receptor-like factor 3 FLJ22729  hypothetical protein FLJ22729 CENTA2 17q11.2 centaurin, alpha 2 RNF135 17q11.2 ring finger protein 135 NF1 17q11.2 neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) OMG 17q11.2 oligodendrocyte myelin glycoprotein EVI2B 17q11.2 ecotropic viral integration site 2B EVI2A 17q11.2 ecotropic viral integration site 2A AK3P1 17q11.2 adenylate kinase 3 pseudogene 1 RAB11-FIP4  rab11-family interacting protein 4 LOC339281 17q11.2 hypothetical LOC339281
RNA
TRANSCRIPTS type messenger
text several transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 8025 180 1380 - O malley
- - - 160 - selectively expressed in several haematopoietic tumour cells O malley
  • has an incomplete N-terminal domain I but intact domains II and III
  • nuclear localization
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines hepatoma cells
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • B type membrane bound metallocarboxypeptidase comprising
  • three tandem active site domains, three CP domains
  • zinc peptide domain
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to duck gp180 (hepatitis virus-binding protein)
    ortholog to murine Cpd
    Homologene
    FAMILY zinc carboxypeptidase family, peptidase M14 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text localizd in the TGN (trans-Golgi network)
    basic FUNCTION carboxypeptidase, involved in secretory pathway
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 zinc ions per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS