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FLASH GENE
Symbol CPB1 contributors: mct - updated : 19-03-2008
HGNC name carboxypeptidase B1 (tissue)
HGNC id 2299
Location 3q24      Physical location : 148.545.587 - 148.577.970
Genatlas name pancreas specific protein
Synonym name
  • carboxypeptidase B, pancreatic
  • pancreatic carboxypeptidase B1
    • Synonym symbol(s) PCYB, PASP, PCPB
    EC.number 3.4.17.2
    DNA
    TYPE functioning gene
    STRUCTURE 32.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZIC4 3q24 Zic family member 4 ZIC1 3q24 Zic family member 1 (odd-paired homolog, Drosophila) LOC339899 3q24 hypothetical LOC339899 LOC391586 3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 LOC344741 3q24 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389159 3 LOC389159 RPL38P1 3q21-q25 ribosomal protein L38 pseudogene 1 AGTR1 3q21-q25 angiotensin II receptor, type 1 CPB1 7p14-p13 carboxypeptidase B1 (tissue) CPA3 3q21-q25 carboxypeptidase A3 (mast cell) LOC285329 3q24 similar to Ataxin-1 ubiquitin-like interacting protein GYG 3q24 glycogenin SMARCA3 3q25.1-q26.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 HPS3 3q24-q25.1 Hermansky-Pudlak syndrome 3 CP 3q23-q25 ceruloplasmin (ferroxidase) LOC389160 3 LOC389160 LOC116441 3q24 hypothetical protein BC014339 TM4SF1 3q21-q25 transmembrane 4 superfamily member 1 TM4SF4 3q25 transmembrane 4 superfamily member 4 TAZ Xq28 tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) LOC51122 3q25.1 HSPC042 protein LOC389161 3 hypothetical gene supported by AK027233 LOC389162 3 LOC389162 LOC389163 3 hypothetical gene supported by AK098078 RNF13 3q25.1 ring finger protein 13 PFN2 3q25.1-q25.2 profilin 2 LOC389164 3 similar to Chromosome 1 open reading frame 37 LOC391587 3 similar to peptidyl-Pro cis trans isomerase LOC389165 3 hypothetical gene supported by AF090923; AK023388; BC002719 LOC389166 3 LOC389166 KIAA0669 3q25.1-q25.2 LOC389166 SERP1 3q25.1 stress-associated endoplasmic reticulum protein 1 eIF2A 3q25.1 eukaryotic translation initiation factor (eIF) 2A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1473 - 417 - Guimaraes (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion secreted in serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 15AA signal/leader peptide
  • a 95AA activation peptide
  • a catalytic moiety with a zinc binding domain
    • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to C.elegans y59c2a.1
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulate the plasminogen system both in the matrix and on the cell surface, thus leading to the inhibition of endothelial cell movement and tube formation
  • cleave off basic C-terminal residues and secreted as inactive zymogens
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    activated by trypsin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene serum marker for acute pancreatitis
    Marker
    Therapy target
    ANIMAL & CELL MODELS