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FLASH GENE
Symbol CPA4 contributors: - updated : 14-04-2005
HGNC name carboxypeptidase A4
HGNC id 15740
Corresponding disease
SRS7 Silver-Russell syndrome
Location 7q32      Physical location : 129.932.973 - 129.964.019
Synonym symbol(s) CPA3, CPB4
EC.number 3.4.17.-
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of a cluster of carboxypeptidase on chromosome 7 with CPA1, CPA2 and CPA5
STRUCTURE 31.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU
text structure sequence SINE/ ALU in the first intron
MAPPING cloned Y linked N status provisional
Physical map
LOC392096 7 similar to Triosephosphate isomerase (TIM) HCP20 7q32.3 cytochrome c, somatic pseudogene LOC286017 7q32.3 similar to mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2 MGC50844 7q32.3 hypothetical protein MGC50844 LOC154981 7q32.3 hypothetical LOC154981 SMO 7q31 smoothened homolog (Drosophila) KIAA0828 7q32.3 KIAA0828 protein KIAA1170 7q32.3 KIAA1170 protein NRF1 7q32 nuclear respiratory factor 1 UBE2H 7q32 ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) NIPA 7q32.3 nuclear interacting partner of anaplastic lymphoma kinase (ALK) KIAA0265 7q32.3 KIAA0265 protein LOC389556 7 LOC389556 FLJ14803 7q32.3 hypothetical protein FLJ14803 LOC136263 7q32.3 LOC136263 CPA2 7q32 carboxypeptidase A2 (pancreatic) CPA4 7q32 carboxypeptidase A4 CPA5 7q32 carboxypeptidase A5 CPA1 7q32 carboxypeptidase A1 (pancreatic) TSGA14 7q32 testis specific, 14 MEST 7q32 mesoderm specific transcript homolog (mouse) COPG2 7q32 coatomer protein complex, subunit gamma 2 TSGA13 7q32 testis specific, 13 KLF14 7q32.3 Kruppel-like factor 14 LOC347674 7q32 ALEX2 pseudogene LOC340349 7q32.3 hypothetical LOC340349 FLJ43663 7q32.3 hypothetical protein FLJ43663 LOC136256 7q32.3 similar to ribosomal protein L27 MKLN1 7q32 muskelin 1, intracellular mediator containing kelch motifs
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING paternally
text paternally imprinted in fetal heart, lung, liver, intestine, kidney adrenal gland, spleen (but not in brain) and in benign hypertrophic prostate
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leader segment
  • an activation peptide and a carboxypeptidase moiety with a zinc binding site
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies paralog to CPA1
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION cleaving substrates with C terminal hydrophobic residues
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    histone hyperacetylation pathway
    a component CPA4/latexin complex
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    inhibited by LXN
    ASSOCIATED DISORDERS
    corresponding disease(s) SRS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS