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FLASH GENE
Symbol CPA2 contributors: mct - updated : 02-05-2014
HGNC name carboxypeptidase A2 (pancreatic)
HGNC id 2297
Location 7q32.2      Physical location : 129.906.702 - 129.929.635
EC.number 3.4.17.15
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of a cluster of carboxypeptidase on chromosome 7 with CPA1, CPA4 and CPA5
STRUCTURE 22.94 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392096 7 similar to Triosephosphate isomerase (TIM) HCP20 7q32.3 cytochrome c, somatic pseudogene LOC286017 7q32.3 similar to mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2 MGC50844 7q32.3 hypothetical protein MGC50844 LOC154981 7q32.3 hypothetical LOC154981 SMO 7q31 smoothened homolog (Drosophila) KIAA0828 7q32.3 KIAA0828 protein KIAA1170 7q32.3 KIAA1170 protein NRF1 7q32 nuclear respiratory factor 1 UBE2H 7q32 ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) NIPA 7q32.3 nuclear interacting partner of anaplastic lymphoma kinase (ALK) KIAA0265 7q32.3 KIAA0265 protein LOC389556 7 LOC389556 FLJ14803 7q32.3 hypothetical protein FLJ14803 LOC136263 7q32.3 LOC136263 CPA2 7q32 carboxypeptidase A2 (pancreatic) CPA4 7q32 carboxypeptidase A4 CPA5 7q32 carboxypeptidase A5 CPA1 7q32 carboxypeptidase A1 (pancreatic) TSGA14 7q32 testis specific, 14 MEST 7q32 mesoderm specific transcript homolog (mouse) COPG2 7q32 coatomer protein complex, subunit gamma 2 TSGA13 7q32 testis specific, 13 KLF14 7q32.3 Kruppel-like factor 14 LOC347674 7q32 ALEX2 pseudogene LOC340349 7q32.3 hypothetical LOC340349 FLJ43663 7q32.3 hypothetical protein FLJ43663 LOC136256 7q32.3 similar to ribosomal protein L27 MKLN1 7q32 muskelin 1, intracellular mediator containing kelch motifs
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1342 - 419 - 2002 11836249
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short leader sequence and a 94 AA long activation peptide
  • a catalytic moiety with a zinc binding domain
  • conjugated MetalloP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • cleaving substrates with C terminal hydrophobic residues
  • CPA1, CPA2 might play a role in the renin-angiotensin system in addition to their functions as digestive enzymes
  • CPA1 and CPA2 act on aromatic and aliphatic amino acid residues that are exposed by the action of chymotrypsins and elastases
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation
  • cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS