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FLASH GENE
Symbol COX7C contributors: npt - updated : 19/11/2008
HGNC name cytochrome c oxidase subunit VIIc
HGNC id 2292
Location 5q14      Physical location : 85.913.783 - 85.916.581
Synonym name cytochrome c oxidase subunit 7C, mitochondrial
Synonym symbol(s) COXO
EC.number 1.9.3.1
DNA
TYPE functioning gene
STRUCTURE 2.80 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DBIL1 5pter-p15.32 diazepam binding inhibitor-like 1 DHFR 5q13.2 dihydrofolate reductase MSH3 5q11-q12 mutS homolog 3 (E. coli) RASGRF2 5q13 Ras protein-specific guanine nucleotide-releasing factor 2 CKMT2 5q13.3 creatine kinase, mitochondrial 2 (sarcomeric) DKFZp761J139 5q14.1 hypothetical protein DKFZp761J139 CACH-1 5q14.1 cytosolic acetyl-CoA hydrolase SSBP2 5q14.1 single-stranded DNA binding protein 2 DSS1P1 5q14 single-stranded DNA binding protein 2 APG10L 5q14.1 APG10 autophagy 10-like (S. cerevisiae) PPIP1 5q14.1 peptidylprolyl isomerase (cyclophilin) pseudogene 1 RPS23 5q13-q14 ribosomal protein S23 LOC92270 5q14.1 hypothetical protein LOC92270 LOC389307 5 LOC389307 LOC391806 5 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein MGC23909 5q14.2 hypothetical protein MGC23909 XRCC4 5q11.2-q13.3 X-ray repair complementing defective repair in Chinese hamster cells 4 CSPG2 5q14.3 chondroitin sulfate proteoglycan 2 (versican) CRTL1 5q14.3 cartilage linking protein 1 EDIL3 5q14 EGF-like repeats and discoidin I-like domains 3 LOC391807 5 similar to peptidyl-Pro cis trans isomerase LOC391808 5 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC391809 5 similar to 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) MGC48637 5q14.3 hypothetical protein MGC48637 COX7C 5q14 cytochrome c oxidase subunit VIIc LOC389308 5 similar to ribosomal protein L10a FLJ11292 5q14.3 hypothetical protein FLJ11292 RASA1 5q13.3 RAS p21 protein activator (GTPase activating protein) 1 CCNH 5q13.3-q14 cyclin H MGC33214 5q14.3 hypothetical protein MGC33214 MEF2C 5q14 MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) CETN3 5q14.3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast) LOC153364 5q14.3 similar to metallo-beta-lactamase superfamily protein like (XL884) RPC32 5q14.3 polymerase (RNA) III (DNA directed) (32kD) LOC116068 5q14.3 hypothetical protein LOC116068 MASS1 5q14.1 monogenic, audiogenic seizure susceptibility 1 homolog (mouse) LOC133790 5q14.3 similar to ribosomal protein S18, cytosolic [validated] - rat KIAA1376 LOC133789 5q14.3 similar to Rab5c protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 448 7 63 - Hofmann (1998)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumear   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • cytochrome c oxidase VIIc family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the elctron transfer from reduced cytochrome c to molecule oxygen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c : oxygen oxidoreductase) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    assembled BAP1/HCFC1/YY1 complex (acts to induce the activation of COX7C or other target genes)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS