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FLASH GENE
Symbol COX7C contributors: npt - updated : 19/11/2008
HGNC name cytochrome c oxidase subunit VIIc
HGNC id 2292
Location 5q14      Physical location : 85.913.783 - 85.916.581
Synonym name cytochrome c oxidase subunit 7C, mitochondrial
Synonym symbol(s) COXO
EC.number 1.9.3.1
DNA
TYPE functioning gene
STRUCTURE 2.80 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 448 7 63 - Hofmann (1998)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumear   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • cytochrome c oxidase VIIc family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the elctron transfer from reduced cytochrome c to molecule oxygen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c : oxygen oxidoreductase) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    assembled BAP1/HCFC1/YY1 complex (acts to induce the activation of COX7C or other target genes)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS