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FLASH GENE
Symbol COX7A2L contributors: - updated : 30-12-2005
HGNC name cytochrome c oxidase subunit VIIa polypeptide 2 like
HGNC id 2289
Location 2p21      Physical location : 42.577.646 - 42.588.356
Synonym name
  • estrogen receptor binding CpG island
  • COX7A related protein
  • Synonym symbol(s) EB1, COX7RP, SIG81, COX7AH, COX7AR
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site   HRE
    text structure two estrogen-responsive palindromic elements, one intronic, one in the 5'utr
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388941 2 similar to hypothetical protein (L1H 3 region) - human LOC391369 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC284397 2p22.1 similar to FKSG60 LOC391370 2 similar to ribosomal protein S12 LOC388942 2 hypothetical gene supported by AK126414 LOC285047 2p22.1 hypothetical LOC285047 LOC91461 2p22.1 hypothetical protein BC007901 EML4 2p22-p21 echinoderm microtubule associated protein like 4 COX7A2L 2p22.1-p16 cytochrome c oxidase subunit VIIa polypeptide 2 like LOC253584 2p22.1 hypothetical LOC253584 KCNG3 2p22.1 potassium voltage-gated channel, subfamily G, member 3 MTA3 2p21 potassium voltage-gated channel, subfamily G, member 3 TG1019 2p22.1 G-protein coupled receptor TG1019 HAAO 2p21 3-hydroxyanthranilate 3,4-dioxygenase LOC388943 2 similar to cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 ZFP36L2 2p22.3 zinc finger protein 36, C3H type-like 2 MGC40574 2p22.1 hypothetical protein MGC40574 THADA 2p22.1 thyroid adenoma associated KIAA2028 2p22.1 similar to PH (pleckstrin homology) domain D2LIC 2p25.1-p24.1 dynein 2 light intermediate chain ABCG5 2p21 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) ABCG8 2p21 ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) LRPPRC 2p21 leucine-rich PPR-motif containing PPM1B 2p22,1 protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform LOC391371 2 similar to 60S RIBOSOMAL PROTEIN L12 SLC3A1 2p16.3 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 FLJ23451 2p22.1 hypothetical protein FLJ23451
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines breast, osteosarcoma
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Sig81 protein
    intraspecies homolog to cytochrome C oxidase subunit VIIa
    Homologene
    FAMILY cytochrome C oxidase 7a family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • putative regulator of COX function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c : oxygen oxidoreductase) complex, terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the electron transfer from reduced cytochrome c to molecule oxygen
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by estrogens,mediating a higher level of energy in target cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS