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FLASH GENE
Symbol COX7A2L contributors: - updated : 30-12-2005
HGNC name cytochrome c oxidase subunit VIIa polypeptide 2 like
HGNC id 2289
Location 2p21      Physical location : 42.577.646 - 42.588.356
Synonym name
  • estrogen receptor binding CpG island
  • COX7A related protein
    • Synonym symbol(s) EB1, COX7RP, SIG81, COX7AH, COX7AR
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site   HRE
    text structure two estrogen-responsive palindromic elements, one intronic, one in the 5'utr
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines breast, osteosarcoma
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Sig81 protein
    intraspecies homolog to cytochrome C oxidase subunit VIIa
    Homologene
    FAMILY cytochrome C oxidase 7a family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • putative regulator of COX function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c : oxygen oxidoreductase) complex, terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the electron transfer from reduced cytochrome c to molecule oxygen
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by estrogens,mediating a higher level of energy in target cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS