Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol COX4I1 contributors: - updated : 22-03-2007
HGNC name cytochrome c oxidase subunit IV isoform 1
HGNC id 2265
Corresponding disease
COX4 subacute necrotizing encephalopathy, Leigh syndrome
Location 16q24.2      Physical location : 85.833.195 - 85.840.605
Synonym name
  • cytochrome c oxidase subunit IV
  • cytochrome c oxidase subunit 4 isoform 1, mitochondrial
    • Synonym symbol(s) COX4L2, COX4, MGC72016
    EC.number 1.9.3.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text 3' of NOC4, head to head orientation
    STRUCTURE 7.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Cox4i1
    Homologene
    FAMILY cytochrome c oxidase IV family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
    • mitochondrial electron transport
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidace c (ferrocytochrome c : oxygen oxidoreductase) complex, terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the electron transfer from reduced cytochrome c to molecule oxygen
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COX4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS