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FLASH GENE
Symbol COX2 contributors: mct/ - updated : 24-10-2012
HGNC name mitochondrially encoded cytochrome c oxidase II
HGNC id 7421
Corresponding disease
MELAS mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome
MTDFN1 deafness late onset, progressive, neurosensory non syndromic 1
MTENC3 mitochondrial encephalomyopathy 3
Location mt      Physical location : -
Synonym name
  • sarcoma antigen NY-SAR-71
  • cytochrome c oxidase subunit II
  • cytochrome c oxidase polypeptide II
  • mitochondrially encoded cytochrome c oxidase II
    • Synonym symbol(s) MTCO2, COII, MT-CO2
    EC.number 1.9.3.1
    DNA
    TYPE functioning gene
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Mitco2
    Homologene
    FAMILY
  • cytochrome coxidase subunit 2 family, Complex IV subunit
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • its expression is heregulin-responsive
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional interaction of SCO1 and COX2 in cytochrome oxidase biogenesis
  • EGFR plays a novel role in modulating mitochondrial function via its association with, and modification of COX2
  • COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase
  • is a LONP1 substrate
    • cell & other
    REGULATION
    induced by lipopolysaccharide (LPS) and pro-inflammatory cytokines correlates with ELF3 induction in monocyte/macrophages
    Phosphorylated by EGFR and SRC, and EGF stimulation reduces COX activity and cellular ATP, an event that is dependent in large part on EGFR localized to the mitochondria
    Other regulated by Ets transcription factor ELF3, in response to endotoxin and other pro-inflammatory stimuli
    ASSOCIATED DISORDERS
    corresponding disease(s) MELAS , MTENC3 , MTDFN1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in mitochondrial proximal myopathy with lactic acidosis (COX deficiency)
    tumoral     --low  
    in prostate tumor
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS