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FLASH GENE
Symbol COTL1 contributors: mct - updated : 28-08-2010
HGNC name coactosin-like 1 (Dictyostelium)
HGNC id 18304
Location 16q24.1      Physical location : 84.599.205 - 84.651.669
Synonym name coactosin-like protein
Synonym symbol(s) CLP, MGC19733, FLJ43657
DNA
TYPE functioning gene
STRUCTURE 52.47 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HSBP1 16q23.3 heat shock factor binding protein 1 MLYCD 16q23-q24 malonyl-CoA decarboxylase OKL38 16q24.1 malonyl-CoA decarboxylase NECAB2 LOC146167 16q24.1 similar to hypothetical protein FLJ10815 MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa LOC161931 16q24.1 testis nuclear RNA-binding protein-like KCNG4 16q24.1 potassium voltage-gated channel, subfamily G, member 4 LOC388302 16 LOC388302 WFDC1 16q24.3 WAP four-disulfide core domain 1 KIAA0703 16q24.2 WAP four-disulfide core domain 1 KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein LOC123855 16q24.1 similar to ENSANGP00000013733 MGC22001 16q24.1 hypothetical protein MGC22001 LOC388303 16 LOC388303 LOC388304 16 LOC388304 KIAA0182 16q24 LOC388304 Pfs2 16q24.1 DNA replication complex GINS protein PSF2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1850 15.8 142 - 2001 11583571
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 pancreas exocrine    
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   predominantly
 tonsils   highly
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • actin depolymerization factor/cofilin-like domain
  • HOMOLOGY
    interspecies ortholog to murine Cotl1
    intraspecies homolog to Dictyostelium protein stimulating autonomous replication
    Homologene
    FAMILY
  • actin-binding proteins ADF family
  • coactosin subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • regulating the actin cytoskeleton
  • in stimulated cells, functioning in a complex together with 5-lipoxygenase (5LO) and membranes, increasing the capacity of 5LO for leukotriene biosynthesis
  • playing a role as a chaperoning scaffold factor, influencing both the stability and the activity of ALOX5
  • binds to and chaperones ALOX5 in the cytosol of neutrophils
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    leukotriene
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to F-actin in a calcium-independent manner
  • and 5 lipoxygenase exclusively from each other
  • binds ALOX5 and promotes leukotrienes formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autoimmune disorders
    Variant & Polymorphism other c.-1124G>T and c. 484G>A polymorphisms of the COTL1 gene might be associated with the genetic susceptibility of autoimmune disorders
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    COTL1/ALOX5 as therapy to reduce leukotriene formation in the cell
    ANIMAL & CELL MODELS