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FLASH GENE
Symbol CORO7 contributors: mct - updated : 26 -08 -20
HGNC name coronin 7
HGNC id 26161
Location 16p13.3      Physical location : 4.404.543 - 4.466.639
Synonym name 70 kDa WD repeat tumor rejection antigen homolog
Synonym symbol(s) FLJ22021, CRN7, FLJ44188, POD1
DNA
TYPE functioning gene
STRUCTURE 62.43 kb     27 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 3673 - 1048 - 2011 21130766
26 - 3599 - 840 - 2011 21130766
28 - 3800 - 907 - 2011 21130766
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text upregulated in brain and developing structures of the immune system in the course of development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two stretches of WD repeats in contrast to the other coronins only having one (8 WD repeats)
HOMOLOGY
Homologene
FAMILY WD-repeat coronin family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
text
  • localizes to the Golgi complex
  • basic FUNCTION
  • playing a role in the organization of intracellular membrane compartments and vesicular trafficking rather than in remodeling the cytoskeleton
  • WD40-repeat protein, targeted to membranes and requiring the presence of cargo in the Golgi complex
  • involved in TOB1 degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi
  • interacts with AP-1 adaptor complex, and participates in the maintenance of the Golgi structure and function
  • TOB1-interacting molecule (a sequence containing two of the six WD motifs in the middle of CORO7 was responsible for the interaction)
  • interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex, suggesting that TOB1 protein is regulated by multiple ubiquitination machineries
  • role of KLHL20-mediated K33-ubiquitination of CORO7 in post-Golgi transport, identifiing a cellular recognition mechanism for this ubiquitin chain type
  • cell & other
    REGULATION
    Other membrane-associated form is phosphorylated on tyrosine residues, whereas the cytosolic form is not
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS