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FLASH GENE
Symbol CORO2A contributors: mct/pgu - updated : 29-01-2020
HGNC name coronin, actin binding protein, 2A
HGNC id 2255
Location 9q22.33      Physical location : 100.883.257 - 100.954.956
Synonym name
  • WD repeat protein IR10
  • coronin 2A
  • coronin-like protein B
  • WD protein IR10
  • WD-repeat protein 2
  • Synonym symbol(s) IR10, WDR2, CLIPNB, CO2A, DKFZp686G19226
    DNA
    TYPE functioning gene
    STRUCTURE 71.70 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see NBCCS
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 5657 59.6 525 - 1996 8985118
    12 splicing 5507 59.6 525 - 1996 8985118
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage highly expressed in cells of the haematopoietic lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five WD-40 repeats an helical region
  • a pleckstrin homology (PH) domain
  • SUMO-interaction motifs (SIMs), required for recruiting SUMOylated LXR to NCoR-occupied pro-inflammatory gene promoters
  • HOMOLOGY
    interspecies homolog to murine Coro2a
    intraspecies homolog to Dictyostelium discoideum coronin
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY regulatory , signaling , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • putatively involved in protein interactions
  • with CFL1, are implicated as factors that can regulate a subset of focal-adhesion-turnover events
  • mediates TLR-induced NCoR turnover by a mechanism involving interaction with oligomeric nuclear actin
  • functions as an NCoR exchange factor that is required for de-repression of TLR target genes in macrophages
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text regulatory of cell mobility
    PATHWAY
    metabolism
    signaling
    a component
  • component of the N-COR complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of NR1H3 with CORO2A requires SUMOylation (possible involvement of deSUMOylating enzymes in negatively regulating NR1H3 repression functions)
  • regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is associated with the malignant phenotype of human colon carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS