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FLASH GENE
Symbol CORO1C contributors: mct/npt - updated : 22-09-2015
HGNC name coronin, actin binding protein, 1C
HGNC id 2254
Location 12q24.11      Physical location : 109.038.888 - 109.125.295
Synonym name
  • coronin 3
  • coronin 1C
  • Synonym symbol(s) EVI65, HCRNN4, CRNN4
    DNA
    TYPE functioning gene
    STRUCTURE 86.44 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3828 53 474 - 2014 25074804
    11 - 3957 - 474 - 2014 25074804
    11 - 3939 - 527 - 2014 25074804
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven WD repeats, which form a beta-propeller structure in N terminus, directly interacting with GST-PLS3
  • C-terminal coiled-coil domain, having a self-oligomerization function, and the beta-propeller structure forms a docking platform for protein-protein interactions
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat coronin family
  • CATEGORY adhesion , structural protein , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • phagosome
  • localizes at the sites of active actin dynamics, such as lamellipodia and membrane ruffles (Samarin 2010)
  • PLS3 and CORO1C are strongly enriched in lamellipodia structures at growing edges under the plasma membrane
  • basic FUNCTION
  • having roles in wound healing, protrusion formation, cell proliferation, cytokinesis, endocytosis, axonal growth, and secretion (Rosentreter 2007)
  • WD-repeat actin-binding proteins known to regulate various cellular processes involving actin dynamics (Samarin 2010)
  • may be playing a role in events that follow the initial F-actin assembly (Rosentreter 2007)
  • required for actin-dependent changes in cell morphology that lead to migration and phagocytosis (Yan 2007)
  • regulate cell motility by coordinating actin filament turnover in lamellipodia of migrating cell (Samarin 2010)
  • negatively regulates epithelial cell migration via FAK-mediated inhibition of cell–matrix adhesion (Samarin 2010)
  • regulates actin-dependent processes, thus important for cell motility
  • in contrast with CORO1A and CORO1B, CORO1C displays highly co-operative binding to actin filaments
  • is also involved in endocytosis and has a second actin-binding site that confers co-operative binding to F-actin
  • in SMA, PLS3 and CORO1C but not TMOD3 play an important role in endocytosis by restoring F-actin-dependent processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • interacts with the ARPC4-complex and cofilin indicating that this family in general is involved in regulating ARPC4-mediated events (Rosentreter 2007)
  • CORO1C and RCC2 guide mesenchymal migration by trafficking RAC1 and controlling GEF exposure
  • interaction with RAC1 to the propeller domain in a manner that differs from that proposed for other coronins
  • two actin-related binding partners of PLS3, are CORO1C, and TMOD3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS