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FLASH GENE
Symbol CORO1C contributors: mct/npt - updated : 22-09-2015
HGNC name coronin, actin binding protein, 1C
HGNC id 2254
Location 12q24.11      Physical location : 109.038.888 - 109.125.295
Synonym name
  • coronin 3
  • coronin 1C
  • Synonym symbol(s) EVI65, HCRNN4, CRNN4
    DNA
    TYPE functioning gene
    STRUCTURE 86.44 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    hSyn 12q24.11 brain synembryn LOC390356 12 similar to translation elongation factor eEF-1 beta chain - rabbit MGC17943 12q24.11 hypothetical protein MGC17943 LOC80298 12q24.1 transcription termination factor-like protein CRY1 12q23-q24.1 cryptochrome 1 (photolyase-like) LOC390357 12 similar to Cca3 protein BTBD11 12q24.11 BTB (POZ) domain containing 11 PWP1 12q24.11 nuclear phosphoprotein similar to S. cerevisiae PWP1 PRDM4 12q23-q24.1 PR domain containing 4 ASCL4 12q24.11 class II bHLH protein ASCL4 LOC390358 12 similar to RET finger protein-like 3 LOC390359 12 similar to programmed cell death 2 isoform 2; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog KIAA0789 12q24.11 similar to programmed cell death 2 isoform 2; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog LOC196469 12q24.11 similar to apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; phorbolin-like protein MDS019 CMKLR1 12q24.1 chemokine-like receptor 1 HYPE 12q24.1 chemokine-like receptor 1 SART3 12q24.1 squamous cell carcinoma antigen recognised by T cells 3 NIFU 12-q24.1 squamous cell carcinoma antigen recognised by T cells 3 LOC338773 12q24.12 hypothetical protein LOC338773 SELPLG 12q24 selectin P ligand CORO1C 12q24.1 coronin, actin binding protein, 1C SSH1 12q24.12 slingshot 1 DAO 12q24.12 D-amino-acid oxidase DKFZp761H039 12q24.12 hypothetical protein DKFZp761H039 USP30 12q23.3 ubiquitin specific protease 30 LOC121642 12q24.12 similar to hypothetical protein 9530023G02 UNG 12q23-q24.1 uracil-DNA glycosylase LOC387883 12 LOC387883 ACACB 12q24.1 acetyl-Coenzyme A carboxylase beta FOXN4 12q24.12 forkhead box N4 LOC387884 12 LOC387884 FLJ37587 12q24.12 hypothetical protein FLJ37587 KCTD10 12q24.12 potassium channel tetramerisation domain containing 10 UBE3B 12q24.12 potassium channel tetramerisation domain containing 10 MMAB MVK 12q24 mevalonate kinase (mevalonic aciduria) MGC14436 12q24.12 hypothetical protein MGC14436 FLJ14721 12q24.12 hypothetical protein FLJ14721 TRPV4 12q24.1 transient receptor potential cation channel, subfamily V, member 4 GLTP 12q24.12 glycolipid transfer protein MGC10854 12q24.12 hypothetical protein MGC10854 GIT2 12q24.1 G protein-coupled receptor kinase-interactor 2 ANKRD13 12q24.12 ankyrin repeat domain 13 LOC144705 12q24.12 hypothetical gene supported by AF086409 CDV-1 12q24.13 carnitine deficiency-associated gene expressed in ventricle 1 ATP2A2 12q24.1 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 HMGA1L3 12q24.13 high mobility group AT-hook 1-like 3 ARPC3 12q24 actin related protein 2/3 complex, subunit 3, 21kDa MGC14560 12q24.13 protein x 0004 HSU79274 12q24.13 protein predicted by clone 23733 VPS29 12q24 vacuolar protein sorting 29 (yeast)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3828 53 474 - 2014 25074804
    11 - 3957 - 474 - 2014 25074804
    11 - 3939 - 527 - 2014 25074804
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven WD repeats, which form a beta-propeller structure in N terminus, directly interacting with GST-PLS3
  • C-terminal coiled-coil domain, having a self-oligomerization function, and the beta-propeller structure forms a docking platform for protein-protein interactions
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat coronin family
  • CATEGORY adhesion , structural protein , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • phagosome
  • localizes at the sites of active actin dynamics, such as lamellipodia and membrane ruffles (Samarin 2010)
  • PLS3 and CORO1C are strongly enriched in lamellipodia structures at growing edges under the plasma membrane
  • basic FUNCTION
  • having roles in wound healing, protrusion formation, cell proliferation, cytokinesis, endocytosis, axonal growth, and secretion (Rosentreter 2007)
  • WD-repeat actin-binding proteins known to regulate various cellular processes involving actin dynamics (Samarin 2010)
  • may be playing a role in events that follow the initial F-actin assembly (Rosentreter 2007)
  • required for actin-dependent changes in cell morphology that lead to migration and phagocytosis (Yan 2007)
  • regulate cell motility by coordinating actin filament turnover in lamellipodia of migrating cell (Samarin 2010)
  • negatively regulates epithelial cell migration via FAK-mediated inhibition of cell–matrix adhesion (Samarin 2010)
  • regulates actin-dependent processes, thus important for cell motility
  • in contrast with CORO1A and CORO1B, CORO1C displays highly co-operative binding to actin filaments
  • is also involved in endocytosis and has a second actin-binding site that confers co-operative binding to F-actin
  • in SMA, PLS3 and CORO1C but not TMOD3 play an important role in endocytosis by restoring F-actin-dependent processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • interacts with the ARPC4-complex and cofilin indicating that this family in general is involved in regulating ARPC4-mediated events (Rosentreter 2007)
  • CORO1C and RCC2 guide mesenchymal migration by trafficking RAC1 and controlling GEF exposure
  • interaction with RAC1 to the propeller domain in a manner that differs from that proposed for other coronins
  • two actin-related binding partners of PLS3, are CORO1C, and TMOD3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS