basic FUNCTION
| WD repeat-containing actin-binding proteins that regulate cell motility |
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regulating leading edge dynamics and cell motility in fibroblasts |
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coordinates Arp2/3 complex and cofilin activities at the leading edge |
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may be involved in cytokinesis and signal transduction |
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required for actin-dependent changes in cell morphology that lead to migration and phagocytosis |
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protects actin filaments from cofilin-induced depolymerization |
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replaces the Arp2/3 complex at actin filament branches as the dendritic network matures and drives the turnover of branched actin networks |
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WD-repeat actin-binding proteins known to regulate various cellular processes involving actin dynamics |
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in contrast with CORO1A and CORO1B, CORO1C displays highly co-operative binding to actin filaments |
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cytoskeleton-related CORO1A and CORO1B proteins control a myosin II inactivation-dependent step that dictates the intracellular dynamics and cytoskeletal output of active RAC1 |
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CORO1A, CORO1B are at the center of a regulatory hub that coordinates RAC1 activation, effector exchange, and the F-actin organization state during cell signaling |