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FLASH GENE
Symbol CORO1B contributors: mct - updated : 20-04-2014
HGNC name coronin, actin-binding protein, 1B
HGNC id 2253
Location 11q13.2      Physical location : 67.205.517 - 67.211.263
Synonym name
  • coronin-2
  • coronin-1B
  • Synonym symbol(s) CORONIN-2, DKFZp762I166
    DNA
    TYPE functioning gene
    STRUCTURE 5.75 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1920 - 489 - 2005 16027158
    11 - 1927 - 489 - 2005 16027158
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     stomach   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five WD repeats
  • mono polymer homomer , octamer
    HOMOLOGY
    Homologene
    FAMILY
  • WD repeat coronin family
  • CATEGORY adhesion , structural protein , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • phagosome
  • localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers
  • localize at the leading edge of lamellipodia
  • basic FUNCTION
  • WD repeat-containing actin-binding proteins that regulate cell motility
  • regulating leading edge dynamics and cell motility in fibroblasts
  • coordinates Arp2/3 complex and cofilin activities at the leading edge
  • may be involved in cytokinesis and signal transduction
  • required for actin-dependent changes in cell morphology that lead to migration and phagocytosis
  • protects actin filaments from cofilin-induced depolymerization
  • replaces the Arp2/3 complex at actin filament branches as the dendritic network matures and drives the turnover of branched actin networks
  • WD-repeat actin-binding proteins known to regulate various cellular processes involving actin dynamics
  • in contrast with CORO1A and CORO1B, CORO1C displays highly co-operative binding to actin filaments
  • cytoskeleton-related CORO1A and CORO1B proteins control a myosin II inactivation-dependent step that dictates the intracellular dynamics and cytoskeletal output of active RAC1
  • CORO1A, CORO1B are at the center of a regulatory hub that coordinates RAC1 activation, effector exchange, and the F-actin organization state during cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • interacts with ARP2/3 complex components, including ACTR2, ARPC1B and ARPC2, interacts simultaneously with Slingshot (SSH1L) phosphatase, two regulators of actin filament formation and turnover, respectively
  • interacting with F-actin (F-actin binding is absolutely required for coronin 1B to exert its effects on whole-cell motility and lamellipodial dynamics)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS