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FLASH GENE
Symbol COQ3 contributors: mct/npt - updated : 10/11/2008
HGNC name coenzyme Q3 homolog, methyltransferase (S. cerevisiae)
HGNC id 18175
Location 6q16.3      Physical location : 99.817.348 - 99.842.082
Synonym name
  • coenzyme Q,methyltransferase COQ3
  • coenzyme Q3 homolog, methyltransferase (yeast)
  • hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
  • 3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase
  • DHHB methyltransferase
  • Synonym symbol(s) bA9819.1, DHHB-MTase, UG0215E05, DHHB-MT
    EC.number 2.1.1.114
    DNA
    TYPE functioning gene
    STRUCTURE 24.73 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1265 41 369 - Jonassen (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepharynx   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative N terminal mitochondrial targeting signal
  • a zinc binding
  • HOMOLOGY
    interspecies homolog to rattus Coq3
    ortholog to yeast S.cerevisiae coq3
    Homologene
    FAMILY
  • methyltransferase superfamily
  • UbiG/COQ3 family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text mitochondria
    basic FUNCTION
  • methyltransferase required for ubiquinone biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
  • biosynthesis of ubiquitone (coenzyme Q)
  • a component
  • Q-biosynthetic COQ polypeptide complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS