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FLASH GENE
Symbol COPZ2 contributors: mct - updated : 28-04-2012
HGNC name coatomer protein complex, subunit zeta 2
HGNC id 19356
Location 17q21.32      Physical location : 46.103.534 - 46.115.152
Synonym name
  • nonclathrin coat protein zeta-COP
  • zeta-2 coat protein
  • Synonym symbol(s) MGC23008, zeta2-COP
    DNA
    TYPE functioning gene
    STRUCTURE 11.62 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure first intron of the COPZ2 gene encodes the precursor of an miRNA, miR-152
    MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ40342 17q21.32 hypothetical protein FLJ40342 NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase MGC11242 17q21.32 hypothetical protein MGC11242 CDK5RAP3 17q21.2 CDK5 regulatory subunit associated protein 3 COPZ2 17q21.3 coatomer protein complex, subunit zeta 2 NFE2L1 17q21.3 nuclear factor (erythroid-derived 2)-like 1 CBX1 17q21.32 chromobox homolog 1 (HP1 beta homolog Drosophila ) SNX11 17q21.2 sorting nexin 11 SCAP1 17q21.32 src family associated phosphoprotein 1 HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 923 23.4 210 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid   highly
    Lymphoid/Immunetonsils   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer oligo , complex
    HOMOLOGY
    interspecies homolog to dog COPZ2 (83 pc)
    homolog to murine Copz2 (91.2 pc)
    Homologene
    FAMILY
  • clathrin adaptor complexes small subunit family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • cis-Golgi network
  • membrane coat
  • basic FUNCTION
  • mediating biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network
  • required for budding from Golgi membranes
  • being essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
  • involved in regulating the coat assembly
  • required by different tumor cell types but is not essential for normal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • ER-Golgi transport
  • intracellular protein transport
  • PATHWAY
    metabolism
    signaling
    a component
  • COPG2/COPZ2 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • harbors microRNA 152, which is silenced in tumor cells concurrently with COPZ2 and acts as a tumor suppressor
  • COPZ1 can substitute functionally for the lack of COPZ2 in tumor cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the majority of tumor cell lines and in clinical samples of different cancer types
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS