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FLASH GENE
Symbol COPZ2 contributors: mct - updated : 28-04-2012
HGNC name coatomer protein complex, subunit zeta 2
HGNC id 19356
Location 17q21.32      Physical location : 46.103.534 - 46.115.152
Synonym name
  • nonclathrin coat protein zeta-COP
  • zeta-2 coat protein
  • Synonym symbol(s) MGC23008, zeta2-COP
    DNA
    TYPE functioning gene
    STRUCTURE 11.62 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure first intron of the COPZ2 gene encodes the precursor of an miRNA, miR-152
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 923 23.4 210 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid   highly
    Lymphoid/Immunetonsils   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer oligo , complex
    HOMOLOGY
    interspecies homolog to dog COPZ2 (83 pc)
    homolog to murine Copz2 (91.2 pc)
    Homologene
    FAMILY
  • clathrin adaptor complexes small subunit family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • cis-Golgi network
  • membrane coat
  • basic FUNCTION
  • mediating biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network
  • required for budding from Golgi membranes
  • being essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
  • involved in regulating the coat assembly
  • required by different tumor cell types but is not essential for normal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • ER-Golgi transport
  • intracellular protein transport
  • PATHWAY
    metabolism
    signaling
    a component
  • COPG2/COPZ2 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • harbors microRNA 152, which is silenced in tumor cells concurrently with COPZ2 and acts as a tumor suppressor
  • COPZ1 can substitute functionally for the lack of COPZ2 in tumor cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the majority of tumor cell lines and in clinical samples of different cancer types
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS