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FLASH GENE
Symbol COPS8 contributors: mct/npt - updated : 11/09/2008
HGNC name COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
HGNC id 24335
Location 2q37.3      Physical location : 237.994.083 - 238.007.487
Synonym name
  • COP9 homolog
  • COP9 signalosome subunit 8 isoform 1
  • COP9 signalosome subunit 8 isoform 2
  • Synonym symbol(s) COP9, CSN8, SGN8, MGC1297, MGC43256
    DNA
    TYPE functioning gene
    STRUCTURE 13.40 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    GBX2 2q37.3 gastrulation brain homeo box 2 LOC389086 2 LOC389086 FLJ22527 2q37.3 hypothetical protein FLJ22527 CMKOR1 2q37.3 chemokine orphan receptor 1 COPS8 2q37.3 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) LOC389087 2 LOC389087 COL6A3 2q37.3 collagen, type VI, alpha 3 LOC285110 2q37.3 hypothetical LOC285110 MLPH 2q37.3 hypothetical LOC285110 PRH 2q37.3 preproprolactin-releasing peptide RAB17 2q37.3 RAB17, member RAS oncogene family LRRFIP1 2q37.3 leucine rich repeat (in FLII) interacting protein 1 FLJ40411 2q37.3 FLJ40411 protein RAMP1 2q36-q37.1 receptor (calcitonin) activity modifying protein 1 NCE2 2q37.3 NEDD8-conjugating enzyme SCLY 2q37.3 selenocysteine lyase LOC339768 2q37.3 hypothetical protein LOC339768 FLJ43374 2q37.3 FLJ43374 protein LOC389088 2 similar to hypothetical protein 4832406C22 ILKAP 2q37.3 integrin-linked kinase-associated serine/threonine phosphatase 2C LOC151174 2q37.3 hypothetical protein LOC151174 LOC391494 2 similar to TAR DNA-binding protein-43 (TDP-43) HES6 2q37.3 hairy and enhancer of split 6 (Drosophila) PER2 2q37.3 period homolog 2 (Drosophila) MIP-T3 2q37.3 microtubule-interacting protein that associates with TRAF3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2279 23 209 - Groisman, Miyauchi (2008)
    9 - 2339 - 160 - Groisman, Miyauchi (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus    
    Nervousbrain    
    Respiratorylung   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PCI domain
  • HOMOLOGY
    Homologene
    FAMILY
  • CSN8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • signalosome regulating differentially the ubiquitin ligase activity in the DDB2 and CKN1 complexes in response to DNA damage
  • increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS