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FLASH GENE
Symbol COPS8 contributors: mct/npt - updated : 11/09/2008
HGNC name COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
HGNC id 24335
Location 2q37.3      Physical location : 237.994.083 - 238.007.487
Synonym name
  • COP9 homolog
  • COP9 signalosome subunit 8 isoform 1
  • COP9 signalosome subunit 8 isoform 2
  • Synonym symbol(s) COP9, CSN8, SGN8, MGC1297, MGC43256
    DNA
    TYPE functioning gene
    STRUCTURE 13.40 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2279 23 209 - Groisman, Miyauchi (2008)
    9 - 2339 - 160 - Groisman, Miyauchi (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus    
    Nervousbrain    
    Respiratorylung   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PCI domain
  • HOMOLOGY
    Homologene
    FAMILY
  • CSN8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • signalosome regulating differentially the ubiquitin ligase activity in the DDB2 and CKN1 complexes in response to DNA damage
  • increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS