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FLASH GENE
Symbol COPS7B contributors: npt/ - updated : 17-11-2009
HGNC name COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
HGNC id 16760
Location 2q37.1      Physical location : 232.651.161 - 232.673.434
Synonym name
  • JAB1-containing signalosome subunit 7b
  • signalosome subunit 7b
  • Synonym symbol(s) SGN8, FLJ2612, CSN7B, MGC111077, SGN7b
    DNA
    TYPE functioning gene
    STRUCTURE 22.27 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ITM2C 2q37 integral membrane protein 2C GPR55 2q37 G protein-coupled receptor 55 TSARG1 LOC389080 2 LOC389080 PSMD1 2q37.1-q37.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 HTR2B 2q36.3-q37.1 5-hydroxytryptamine (serotonin) receptor 2B FLJ12584 2q37.1 hypothetical protein FLJ12584 FLJ23510 2q37.1 hypothetical protein FLJ23510 LOC389081 2 LOC389081 B3GNT7 2q36.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 LOC389082 2 similar to archease NCL 2q12-qter nucleolin MGC43122 2q37.1 hypothetical protein MGC43122 GPR66 2q37.1 G protein-coupled receptor 66 LOC391490 2 similar to 60S ribosomal protein L23a MGC35154 2q37.1 hypothetical protein MGC35154 MGC4771 2q37.1 hypothetical protein MGC4771 PTMA 2q36-q36 prothymosin, alpha (gene sequence 28) PDE6D 2q36 phosphodiesterase 6D, cGMP-specific, rod, delta COPS7B 2q36.2 COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) LOC391491 2 similar to guanidinoacetate methyltransferase; GAMT NPPC 2q24-qter natriuretic peptide precursor C MGC42174 2q37.1 hypothetical protein MGC42174 ALPP 2q37.1 alkaline phosphatase, placental (Regan isozyme) ALPPL2 2q37 alkaline phosphatase, placental-like 2 LOC391492 2 similar to xce ALPI 2q37.1 alkaline phosphatase, intestinal ECEL1 2q36-q37 endothelin converting enzyme-like 1 LOC389083 2 similar to enterokinase CHRND 2q37 cholinergic receptor, nicotinic, delta polypeptide CHRNG 2q37.1-q37.2 cholinergic receptor, nicotinic, gamma polypeptide TIGD1 2q36.1 tigger transposable element derived 1 EIF4EL3 2q37.3 eukaryotic translation initiation factor 4E-like 3 FLJ13612
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1977 - 264 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PCI (Proteasome,COP9,initiation factor 3) domain
  • INT6 domain
  • NIP1 and TRIP15 domain
  • HOMOLOGY
    interspecies ortholog to Arabidopsis COP9 subunit 7B
    intraspecies paralog to components of the regulatory subunit of 26S proteasome
    paralog to EIF3s family
    Homologene
    FAMILY
  • COP9 signalosome family
  • CSN7/EIF3M family
  • CSN7 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • potential cellular regulator modulating multiple signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a signalosome complex GPS1 450kDa including COPS3, COPS4, COPS5/JAB1, COPS6, COPS7A, COPS7B, GPS1, TRIP15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS