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FLASH GENE
Symbol COPS4 contributors: npt/ - updated : 19-07-2007
HGNC name COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
HGNC id 16702
Location 4q21.22      Physical location : 83.956.238 - 83.996.970
Synonym name
  • JAB1 containing signalosome subunit 4
  • signalosome subunit 4
  • COP9 signalosome subunit 4
  • Synonym symbol(s) CSN4, MGC10899, MGC15160, SGN4
    DNA
    TYPE functioning gene
    STRUCTURE 40.73 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPS25P1 4q21.23 mitochondrial ribosomal protein S25 pseudogene MGC35043 4q21.3 hypothetical protein MGC35043 BMP3 4p14-q21 bone morphogenetic protein 3 (osteogenic) PRKG2 4q13.1-q21.1 protein kinase, cGMP-dependent, type II GPIG4 COX5BL1 4cen-q31 cytochrome c oxidase subunit Vb-like 1 LOC345258 4q21.3 similar to bridging integrator 2; bridging integrator-2; breast cancer associated protein BRAP1 HNRPD 4q21.1-q21.2 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) LOC391672 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) HNRPDL 4q13-q21 heterogeneous nuclear ribonucleoprotein D-like MASA 4q21.3 E-1 enzyme LOC391673 4 similar to protein-tyrosine phosphatase SCD4 4q21.3 stearoyl-CoA desaturase 4 KIAA0905 4q21.3 stearoyl-CoA desaturase 4 THAP9 4q21.3 THAP domain containing 9 DKFZp686L1814 4q21.3 hypothetical protein DKFZp686L1814 COPS4 4q21.21-q21.23 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) PLAC8 4q21.22 placenta-specific 8 LOC391674 4 similar to Aminomethyltransferase, mitochondrial precursor (Glycine cleavage system T protein) (GCVT) CL640 4q21.3 hypothetical protein CL640 HPSE 4q21.3 heparanase HEL308 4q21.3 DNA helicase HEL308 MRPS18C 4q21.3 mitochondrial ribosomal protein S18C FLJ13614 4q21.21-q21.23 hypothetical protein FLJ13614 MGC11324 4q21.3 hypothetical protein MGC11324 LOC152845 4q21.3 similar to product similar to X.laevis finger protein. NKX6-1 4q21.2-q22 NK6 transcription factor related, locus 1 (Drosophila) CDS1 4q21 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 WDFY3 4q21.23 WD repeat and FYVE domain containing 3 LOC391675 4 LOC391675
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1765 46.14 406 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PCI (Proteasome,COP9,initiation factor 3) domain
  • INT6 domain
  • NIP1 and TRIP15 domain
  • HOMOLOGY
    interspecies homolog to Arabidopsis subunit 4
    intraspecies paralog to components of the regulatory subunit 26S proteasome
    paralog to EIF3s family
    Homologene
    FAMILY
  • CSN4 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • potential cellular regulator modulating multiple signaling pathways
  • phosphorylating IKBA, JUN, NFKB1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a signalosome complex GPS1 450kDa including COPS3, COPS4, COPS5/JAB1, COPS6, COPS7A, COPS7B, GPS1, TRIP15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS