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FLASH GENE
Symbol COPS3 contributors: npt/ - updated : 19-07-2007
HGNC name COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
HGNC id 2239
Location 17p11.2      Physical location : 17.150.140 - 17.184.591
Synonym name
  • JAB1 containing signalosome subunit 3
  • COP9 complex subunit 3
  • signalosome subunit 3
    • Synonym symbol(s) COP9, SGN3, CSN3
    DNA
    TYPE functioning gene
    STRUCTURE 34.45 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see SMCR (phenotype)
    regionally located within the Smith-Magenis critical region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1652 47.74 423 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PCI (Proteasome,COP9,initiation factor 3) domain
  • INT6 domain
  • NIP1 and TRIP15 domain
    • HOMOLOGY
    interspecies homolog to Arabidopsis subunit 3
    intraspecies homolog to components of the regulatory subunit of 26S proteasome
    homolog to homology to regulatory components of hte 26A proteasome
    Homologene
    FAMILY
  • CSN3 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • potential cellular regulator modulating multiple signaling pathways
  • phosphorylating regulators, IKBA, JUN, NFKB1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a signalosome complex GPS1 450kDa including COPS3, COPS4, COPS5/JAB1, COPS6, COPS7A, COPS7B, GPS1, TRIP15
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS