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FLASH GENE
Symbol COPS2 contributors: mct/npt - updated : 28-03-2009
HGNC name COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
HGNC id 30747
Location 15q21.1      Physical location : 49.417.472 - 49.447.854
Synonym name
  • Alien
  • COP9 (constitutive photomorphogenetic,Arabidopsis,homolog) subunit 2
  • thyroid hormone receptor interactor 15
  • COP9 signalosome complex subunit 2
  • JAB1-containing signalosome subunit 2
  • alien homolog
  • Synonym symbol(s) TRIP15, CSN2, ALIEN, SGN2
    DNA
    TYPE functioning gene
    STRUCTURE 28.24 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 4103 51.5 443 - Tenbaum (2007)
    13 - 4124 52.3 450 - Tenbaum (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    cell cycle     cell cycle, G1, G2, G1S
    Text increased during G1, G1/S and G2 phase
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PCI (proteasome, COP9, initiation factor 3) domain
  • INT6 domain
  • NIP1 and TRIP15 domain
  • HOMOLOGY
    interspecies ortholog to Drosophila Alien
    intraspecies paralog to components of the regulatory lid subunits of the 26S proteasome
    Homologene
    FAMILY
  • COP9 signalosome family
  • CSN2 family
  • CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • acts as a corepressor for E2F1 and is involved in cell cycle regulation (Tenbaum 2007)
  • mediates gene silencing and represses the transactivation of specific nuclear hormone receptor (NHR) superfamily and other transcription factors to modulate hormone response and cell proliferation (Papaioannou 2007)
  • acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly (Papaioannou 2007)
  • corepressor of thyroid hormone receptor
  • potential cellular regulator modulating multiple signaling pathways
  • putative tumor suppressor
  • playing a critical role for cell proliferation/survival and the eventual pathway to control tumorigenesis
  • phosphorylating IKBA, JUN, NFKB1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • component of a signalosome complex GPS1 450kDa including COPS3, COPS4, COPS5/JAB1, COPS6, COPS7A, COPS7B, GPS1, TRIP15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • thyroid receptor in the absence of the hormone
  • activating/stabilizing cJUN independantly of JNK
  • NR0B1
  • IRF8
  • interacting factor of the cell cycle regulator E2F1 (recruited to the E2F binding sites present in the E2F1 gene promoter, inhibits the transactivation of E2F1 and represses endogenous E2F1 gene expression) (Tenbaum 2007)
  • interacting with TRIP11 (interacting within a network of proteins involved in transcriptional regulation, DNA repair, and cell cycle including nucleophosmin, ERCC3, as well as CRSP3) (Kob 2007)
  • interacting partner for MAP3K10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS