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FLASH GENE
Symbol COPA contributors: mct/npt - updated : 20-08-2015
HGNC name coatomer protein complex, subunit alpha
HGNC id 2230
Location 1q23.3      Physical location : 160.258.377 - 160.313.354
Synonym name
  • alpha coat protein
  • xenin
  • proxenin
    • Synonym symbol(s) FLJ26320, HEP-COP, AILJK
    DNA
    TYPE functioning gene
    SPECIAL FEATURE antisens
    STRUCTURE 54.98 kb     33 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see VANGL2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 5639 138.3 1224 - 2014 24489756
    33 - 5666 - 1233 - 2014 24489756
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Hearing/Equilibriumear   highly
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six WD-40 repeat motifs in the N terminal region
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae alpha subunit of coatomer protein complex
    Homologene
    FAMILY
    CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • typically Golgi associated, in neuronal cells COPA localizes to lamellipodia and growth cones and moves within the axon, with a subset of these granules traveling together with SMN1
    • basic FUNCTION
  • involved in the transport between the endoplasmic reticulum and Golgi
  • stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone
  • inhibit pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility
  • SLC4A4 and the trafficking regulator gene COPA, plays an important role in early endosome maturation
  • COPA and SLC4A4 are required for cellular entry of arginine-rich peptides
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the coat of the non-clathrin-coated vesicles
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMN1-binding partner, implicating this protein complex in normal SMN1 function, and this interaction serves an important function in the growth and maintenance of motor neuron processes and may play a significant role in the pathogenesis of SMA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease
    Variant & Polymorphism other
  • COPA variants impair binding to proteins targeted for retrograde Golgi-to-ER transport and is associated to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS