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FLASH GENE
Symbol COPA contributors: mct/npt - updated : 20-08-2015
HGNC name coatomer protein complex, subunit alpha
HGNC id 2230
Location 1q23.3      Physical location : 160.258.377 - 160.313.354
Synonym name
  • alpha coat protein
  • xenin
  • proxenin
  • Synonym symbol(s) FLJ26320, HEP-COP, AILJK
    DNA
    TYPE functioning gene
    SPECIAL FEATURE antisens
    STRUCTURE 54.98 kb     33 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see VANGL2
    Physical map
    LOC127385 1q23.1 similar to Olfactory receptor 10J5 LOC391122 1 similar to porcine serum amyloid P component (SAP) APCS 1q23.2 amyloid P component, serum LOC339511 1q23.1 similar to Olfactory receptor 10J6 LOC171422 1q23.1 C-reactive protein pseudogene CRP 1q23.2 C-reactive protein, pentraxin-related FLJ20442 1q23.1 hypothetical protein FLJ20442 LOC343413 1q23.1 similar to Fc receptor homolog expressed in B cells; Fc receptor related protein X SLAMF8 1q23.1 SLAM family member 8 LOC391123 1 similar to hypothetical protein A030011M19 NESG1 1q22 similar to hypothetical protein A030011M19 TAGLN2 1q22 transgelin 2 IGSF9 1q22-q23 immunoglobulin superfamily, member 9 SLAMF9 1q23.1 SLAM family member 9 LOC391124 1 similar to ribosomal protein L27a; ribosomal protein L29 homolog (yeast) PIGM 1q22 phosphatidylinositol glycan, class M KCNJ10 1q22 potassium inwardly-rectifying channel, subfamily J, member 10 KCNJ9 1q22 potassium inwardly-rectifying channel, subfamily J, member 9 IGSF8 1q23.1 immunoglobulin superfamily, member 8 ATP1A2 1q22 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide ATP1A4 1q22 ATPase, Na+/K+ transporting, alpha 4 polypeptide CASQ1 1q22 calsequestrin 1 (fast-twitch, skeletal muscle) PEA15 1q22 phosphoprotein enriched in astrocytes 15 H326 1q22-q23 H326 LOC388707 1 hypothetical gene supported by BC005391; NM_002295 COPA 1q22 coatomer protein complex, subunit alpha PXF 1q22 peroxisomal farnesylated protein NCSTN 1q22 peroxisomal farnesylated protein NHLH1 1q22 nescient helix loop helix 1 VANGL2 1q22 vang-like 2 (van gogh, Drosophila) SLAMF6 1q23.1 SLAM family member 6 CD84 1q22-q23 CD84 antigen (leukocyte antigen) SLAMF1 1q21.3-1q23.2 signaling lymphocytic activation molecule family member 1 CD48 1q23 CD48 antigen (B-cell membrane protein) SLAMF7 1q23.1-q24.1 SLAM family member 7 LY9 1q21.3-q22 lymphocyte antigen 9 CD244 1q23.1 CD244 natural killer cell receptor 2B4 ITLN1 1q21.3 intelectin 1 (galactofuranose binding) LOC284679 1q23.1 similar to spermine synthase; spermidine aminopropyltransferase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 5639 138.3 1224 - 2014 24489756
    33 - 5666 - 1233 - 2014 24489756
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Hearing/Equilibriumear   highly
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six WD-40 repeat motifs in the N terminal region
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae alpha subunit of coatomer protein complex
    Homologene
    FAMILY
    CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • typically Golgi associated, in neuronal cells COPA localizes to lamellipodia and growth cones and moves within the axon, with a subset of these granules traveling together with SMN1
  • basic FUNCTION
  • involved in the transport between the endoplasmic reticulum and Golgi
  • stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone
  • inhibit pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility
  • SLC4A4 and the trafficking regulator gene COPA, plays an important role in early endosome maturation
  • COPA and SLC4A4 are required for cellular entry of arginine-rich peptides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the coat of the non-clathrin-coated vesicles
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMN1-binding partner, implicating this protein complex in normal SMN1 function, and this interaction serves an important function in the growth and maintenance of motor neuron processes and may play a significant role in the pathogenesis of SMA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease
    Variant & Polymorphism other
  • COPA variants impair binding to proteins targeted for retrograde Golgi-to-ER transport and is associated to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS