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FLASH GENE
Symbol COMMD6 contributors: mct - updated : 14-04-2021
HGNC name COMM domain containing 6
HGNC id 24015
Location 13q22.2      Physical location : 76.099.349 - 76.111.991
Synonym name
  • Acrg embryonic lethality (mouse) minimal region ortholog
  • AK000009 gene
  • copper metabolism gene MURR1 domain 6
  • Synonym symbol(s) ACRGL
    DNA
    TYPE functioning gene
    STRUCTURE 24.23 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1708 - 98 ubiquitous (except skeletal muscle), highly in liver and kidney 2019 31523056
    4 - 1669 - 85 - 2019 31523056
    4 - 1849 - 58 ubiquitous (except skeletal muscle), highly in liver and kidney 2019 31523056
    3 - 1696 - 58 - 2019 31523056
    5 - 1834 - 58 - 2019 31523056
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Hearing/Equilibriumearinnercochlea highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • COMM (copper metabolism gene MURR1) domain
  • HOMOLOGY
    Homologene
    FAMILY MURR1/COMMD1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs
  • may modulate the ubiquitination and degradation of NF-&
  • 954;B subunits and regulate ribonucleoprotein and spliceosome complex biogenesis in tumours
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein inhibit TNF (tumour necrosis factor)-induced NF-kappaB activation in a non-synergistic manner
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in several non-small cell lung cancer (NSCLC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for tumour prevention
  • Therapy target
    ANIMAL & CELL MODELS