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FLASH GENE
Symbol COMMD5 contributors: - updated : 14-02-2007
HGNC name COMM domain containing 5
HGNC id 17902
Location 8q24.3      Physical location : 146.075.551 - 146.078.932
Synonym name
  • hypertension-related calcium-regulated gene
  • COMM domain protein 5
  • Synonym symbol(s) FLJ13008, HCARG, HT002, MGC72046
    DNA
    TYPE functioning gene
    STRUCTURE 15.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1475 25 224 - Burstein
    - - 1320 25 224 - Burstein
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     stomach    
    Endocrineadrenal gland    
    Lymphoid/Immunelymph node   highly
    Skin/Tegumentskin   highly
    Urinarykidneytubule   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a mutated calcium-binding site (EF-hand motif)
  • four putative "leucine zipper" motifs
  • a nuclear receptor-binding domain
  • COMM (copper metabolism gene MURR1) domain
  • HOMOLOGY
    Homologene
    FAMILY MURR1/COMMD1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ regulated
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS