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FLASH GENE
Symbol COL5A3 contributors: mct/npt - updated : 07-07-2010
HGNC name collagen, type V, alpha 3
HGNC id 14864
Location 19p13.2      Physical location : 10.070.236 - 10.121.147
Synonym name pro-(alpha)3(V) collagen
DNA
TYPE functioning gene
STRUCTURE 50.91 kb     67 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site   transcription factor   HRE
text structure
  • core promoter, which lacks a typical TATA motif and has a high GC content, was defined within the -129 bp immediately upstream from the major transcription start site (Nagato 2004)
  • Sp1 binds to the Col5a3 promoter and Sp1 increased the activity (Yun-Feng 2010)
  • MAPPING cloned Y linked N status provisional
    Physical map
    FLJ31986 19p13.2 hypothetical protein FLJ31986 LOC342967 19p13.2 similar to actin 3 - fruit fly (Drosophila melanogaster) (fragments) ZNF426 19p13.2 zinc finger protein 426 MGC45408 19p13.2 hypothetical protein MGC45408 FLJ20079 19p13.2 hypothetical protein FLJ20079 LOC342969 19p13.2 similar to hypothetical protein MGC45408 LOC390887 19 similar to hypothetical protein MGC45408 LOC162993 19p13.2 hypothetical protein LOC162993 UBE2L4 19q13.1-q13.2 ubiquitin-conjugating enzyme E2L 4 FBXL12 19p13.2 F-box and leucine-rich repeat protein 12 PIN1 19p13.2 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 UBL5 19p13.3 ubiquitin-like 5 LOC390888 19 similar to 60S ribosomal protein L10 (QM protein homolog) OLFM2 19p13.2 olfactomedin 2 COL5A3 19p13.2 collagen, type V, alpha 3 RDH8 19p13.2-p13.3 retinol dehydrogenase 8 (all-trans) LOC388502 19 similar to Complement C3 precursor LOC388503 19 similar to Complement C3-1 LOC147740 19p13.2 similar to complement C3 protein (GPC3) precursor FLJ11286 19p13.2 hypothetical protein FLJ11286 ANGPTL6 19p13.2 angiopoietin-like 6 PPAN 19p13 peter pan homolog (Drosophila) P2RY11 19p13.2 purinergic receptor P2Y, G-protein coupled, 11 EIF3S4 19p13.2 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa DNMT1 19p13.2 DNA (cytosine-5-)-methyltransferase 1 EDG5 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 LOC388504 19 LOC388504 MRPL4 19p13.2 mitochondrial ribosomal protein L4 ICAM1 19p13.3-p13.2 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ICAM4 19p13.2-cen intercellular adhesion molecule 4, Landsteiner-Wiener blood group ICAM5 19p13.2 intercellular adhesion molecule 5, telencephalin LOC388505 MGC19604 19p13.2 similar to RIKEN cDNA B230118G17 gene RAVER1 19p13.2 RAVER1 ICAM3 19p13.3-p13.2 intercellular adhesion molecule 3 TYK2 19p13.2 tyrosine kinase 2 CDC37 19p13.2 CDC37 cell division cycle 37 homolog (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    67 - 6192 - 1745 - Mann (1992)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreast   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • fibrillar collagen family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • incorporated into, and contributing to regulate the shape and diameter of type I collagen fibrils
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating as a low abundance collagen, with collagen type I fibrils
  • interacting with SP7 (binds to the Sp1 binding site, in the activation of the COL5A3 gene during osteoblast differentiation) (Yun-Feng 2010)
  • cell & other
    REGULATION
    Other regulated by BMP1 (procollagen C-peptidase)
    regulated by SP7(regulating the COL5A3 gene in osteoblastic cells )(Yun-Feng 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS