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FLASH GENE
Symbol COL5A3 contributors: mct/npt - updated : 07-07-2010
HGNC name collagen, type V, alpha 3
HGNC id 14864
Location 19p13.2      Physical location : 10.070.236 - 10.121.147
Synonym name pro-(alpha)3(V) collagen
DNA
TYPE functioning gene
STRUCTURE 50.91 kb     67 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site   transcription factor   HRE
text structure
  • core promoter, which lacks a typical TATA motif and has a high GC content, was defined within the -129 bp immediately upstream from the major transcription start site (Nagato 2004)
  • Sp1 binds to the Col5a3 promoter and Sp1 increased the activity (Yun-Feng 2010)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    67 - 6192 - 1745 - Mann (1992)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreast   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • fibrillar collagen family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • incorporated into, and contributing to regulate the shape and diameter of type I collagen fibrils
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating as a low abundance collagen, with collagen type I fibrils
  • interacting with SP7 (binds to the Sp1 binding site, in the activation of the COL5A3 gene during osteoblast differentiation) (Yun-Feng 2010)
  • cell & other
    REGULATION
    Other regulated by BMP1 (procollagen C-peptidase)
    regulated by SP7(regulating the COL5A3 gene in osteoblastic cells )(Yun-Feng 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS