SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus,nucleoplasm
|
text
| is found in plasma and in the extracellular matrix |
basic FUNCTION
| protein serine/threonine kinase II |
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phosphorylating the Goodpasture antigen (COL4A3) |
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mediating nonvesicular transfer of ceramide from the endoplasmic reticulum to the Golgi complex |
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critical role for protein kinase D activation and protein kinase D-dependent protein cargo transport to the plasma membrane |
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cooperative control of its functionally distinct domains is a novel molecular event to regulate the intracellular trafficking of ceramide |
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may serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus |
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implicated in a multicompartmental program for protein secretion including phosphorylation and regulation of protein molecular/supramolecular organization and interorganelle ceramide trafficking and regulation of protein cargo transport to the plasma membrane |
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plays an important role in central nervous system neuron function |
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orchestrate a biological program that regulates protein folding and secretion |
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is responsible for the non-vesicular trafficking of ceramide between the endoplasmic reticulum and Golgi |
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exportable non-conventional Ser/Thr kinase that regulating glomerular basement membrane collagen organization |
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directs myofibril formation, an observation that expands its reported role in supramolecular organization of structural proteins to the intracellular compartment |
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it is likely that during cellular stress, disassembly of Golgi structure together with inactivation of COL4A3BP by caspases causes a reduction in ceramide trafficking and SM (sphingomyelin) synthesis, and could contribute to the cellular response to pro-apoptotic stress |
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contribute to deterioration of mitochondrial structure and function in aging oocytes |
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role of COL4A3BP in innate immunity, especially in the clearance of apoptotic cells |
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mediates the inter-organelle transport of ceramide for the synthesis of sphingomyelin, presumably through endoplasmic reticulum (ER)-Golgi membrane contact sites |
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transfers ceramide from the endoplasmic reticulum (ER) to the Golgi complex |