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FLASH GENE
Symbol COIL contributors: mct - updated : 12-03-2011
HGNC name coilin
HGNC id 2184
Location 17q22      Physical location : 55.015.562 - 55.038.411
Synonym name coilin p80
Synonym symbol(s) PNCNB, CLN80, p80-coilin
DNA
TYPE functioning gene
STRUCTURE 22.85 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC390804 17 similar to Glycyl-tRNA synthetase (Glycine--tRNA ligase) (GlyRS) LOC342599 17q23.1 similar to PEPD protein FLJ10970 17q23.1 hypothetical protein FLJ10970 PCTP 17q21-q22 phosphatidylcholine transfer protein FLJ38335 17q23.1-q23.2 hypothetical protein FLJ38335 LOC342600 17q23.2 similar to hypothetical protein 4932411E22 NOG 17q22 noggin DGKE 17q22 diacylglycerol kinase, epsilon 64kDa ZNF147 17q22 zinc finger protein 147 (estrogen-responsive finger protein) COIL 17q22-q23 coilin RISC 17q23.2 coilin LOC376412 17q23.2 ring finger protein 126 pseudogene AKAP1 17q21-q23 a kinase (PRKA) anchor protein 1 MSI2 17q23.1 musashi homolog 2 (Drosophila) FLJ11710 17q23.2 hypothetical protein FLJ11710 MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2649 - 576 - 2010 20875822
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus is responsible for self-association leading to the characteristic fibrous pattern observed in Cajal bodies
  • two nuclear localization signal sequences (NLS)
  • a region rich in arginine and glycine (RG-box)
  • C-terminal region contains a Tudor domain, atypical due to the presence of several unstructured loops, one greater than thirty AAs in length
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    intracellular,nucleus,nucleolus
    text protein of the non-capsular nuclear bodies (coiled bodies), in interphase cells
    basic FUNCTION
  • with SMN have several putative motifs of SUMO-1 modification, suggesting that the sumoylation of COIL and/or SMN might play a role in the molecular reorganization of Cajal bodies during the neuronal differentiation or stress-response
  • integral component of Cajal bodies (also called coiled bodies), nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs
  • plays a role in Cajal body formation
  • nucleoplasmic coilin participates in the regulation of DNA repair
  • nuclear phosphoprotein that concentrates within Cajal bodies (CBs) and impacts snRNP (small nuclear ribonucleoprotein) biogenesis
  • having a function, independent of its role in snRNP biogenesis, establishing a new link between the DNA damage response (DDR) and the inhibition of rRNA synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the most critical components of the Cajal body
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATXN1 (implicated in altering the function of ataxin-1)
  • interacts with XRCC5 and XRCC6, which are major players in the DNA repair process
  • cell & other
    REGULATION
    Phosphorylated by in Ser184 by both VRK1 and VRK2 (COIL colocalizes and interacts with VRK1 in Cajal bodies, but not with the mutant VRK1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS