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FLASH GENE
Symbol COG8 contributors: mct - updated : 28-01-2014
HGNC name component of oligomeric golgi complex 8
HGNC id 18623
Corresponding disease
CDG2H congenital disorder of glycosylation, type 2H
Location 16q22.1      Physical location : 69.362.523 - 69.373.526
Synonym name
  • dependent on RIC1
  • conserved oligomeric Golgi complex component 8
  • Synonym symbol(s) DOR1, FLJ22315
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    text overlap between the COG8 and PDF was initiated by the gain of a novel splice donor site between the COG8 stop codon and PDF initiation codon
    STRUCTURE 11.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC339065 16q22.1 similar to putative membrane-bound dipeptidase-2 DDX28 16q22.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 FLJ20399 16q22.1 hypothetical protein FLJ20399 NFATC3 16q22.1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 FLJ21918 16q22.1 hypothetical protein FLJ21918 LYPLA3 16q22.1 lysophospholipase 3 (lysosomal phospholipase A2) SLC7A6 16q22.1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 FLJ13291 16q22.1 hypothetical protein FLJ13291 FLJ10640 16q22.1 hypothetical protein FLJ10640 FLJ22593 16q22.1 hypothetical protein FLJ22593 SMPD3 16q22.2 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) ZFP90 16q22.1 zinc finger protein 90 homolog (mouse) CDH3 16q22.1 cadherin 3, type 1, P-cadherin (placental) CDH1 16q22.1 cadherin 1, type 1, E-cadherin (epithelial) FLJ12331 16q22.1 hypothetical protein FLJ12331 HAS3 16q22.1 hyaluronan synthase 3 FLJ20400 16q22.1 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) CIRH1A 16q22.1 cirrhosis, autosomal recessive 1A (cirhin) SNTB2 16q22-q23 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) VPS4A 16q23.1 vacuolar protein sorting 4A (yeast) COG8 16q22.1 component of oligomeric golgi complex 8 PDF 16q22.1 peptide deformylase-like protein CGI-37 16q22.1 comparative gene identification transcript 37 MGC23911 16q22.1 hypothetical protein MGC23911 TERF2 16q22.1 telomeric repeat binding factor 2 CYB5-M 16q22.1 cytochrome b5 outer mitochondrial membrane precursor NFAT5 16q22.1 nuclear factor of activated T-cells 5, tonicity-responsive NQO1 16q12-q22 NAD(P)H dehydrogenase, quinone 1 NOB1P 16q22.3 likely ortholog of mouse nin one binding protein LOC388285 16 hypothetical gene supported by U89867; NM_007363 WWP2 16q22.1 Nedd-4-like ubiquitin-protein ligase LOC348174 16q22.1 secretory protein LOC348174 LOC390737 16 similar to MGC9515 protein LOC283970 16q22.1 hypothetical protein LOC283970 PDPR 16q22.1 pyruvate dehydrogenase phosphatase regulatory subunit MGC34761 16q22.1 hypothetical protein MGC34761 LOC388286 16 hypothetical gene supported by AF395444; NM_014006 MTR3 16q22.1 homolog of yeast mRNA transport regulator 3 AARS 16q22.1 alanyl-tRNA synthetase DDX19 16q22.1 DEAD (Asp-Glu-Ala-As) box polypeptide 19 FLJ11126 16q22.1 hypothetical protein FLJ11126 SIAT4B 16q22.3 sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase) FUK 16q22.1 fucokinase COG4 16q22.3 component of oligomeric golgi complex 4 SF3B3 16q22.1 splicing factor 3b, subunit 3, 130kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2522 - 612 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Respiratorylung    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    smellnose
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal coiled-coil region
  • Dor1-like family domain
  • HOMOLOGY
    interspecies ortholog to murine Cog8
    Homologene
    FAMILY
  • COG8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • playing a critical role for the structure and function of the Golgi apparatus and can influence intracellular membrane trafficking
  • playing an essential role in COG complex assembly or stability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COG8-STX16 interactions (COG8 protein initiate the formation of two different tethering platforms that can facilitate the redirection of two populations of Golgi transport intermediates to the mitochondrial vicinity)
  • cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Cog8
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION playing a critical role for the structure and function of the Golgi apparatus and can influence intracellular membrane trafficking
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2H
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS