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FLASH GENE
Symbol COG8 contributors: mct - updated : 28-01-2014
HGNC name component of oligomeric golgi complex 8
HGNC id 18623
Corresponding disease
CDG2H congenital disorder of glycosylation, type 2H
Location 16q22.1      Physical location : 69.362.523 - 69.373.526
Synonym name
  • dependent on RIC1
  • conserved oligomeric Golgi complex component 8
  • Synonym symbol(s) DOR1, FLJ22315
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    text overlap between the COG8 and PDF was initiated by the gain of a novel splice donor site between the COG8 stop codon and PDF initiation codon
    STRUCTURE 11.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2522 - 612 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Respiratorylung    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    smellnose
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal coiled-coil region
  • Dor1-like family domain
  • HOMOLOGY
    interspecies ortholog to murine Cog8
    Homologene
    FAMILY
  • COG8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • playing a critical role for the structure and function of the Golgi apparatus and can influence intracellular membrane trafficking
  • playing an essential role in COG complex assembly or stability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COG8-STX16 interactions (COG8 protein initiate the formation of two different tethering platforms that can facilitate the redirection of two populations of Golgi transport intermediates to the mitochondrial vicinity)
  • cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Cog8
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION playing a critical role for the structure and function of the Golgi apparatus and can influence intracellular membrane trafficking
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2H
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS